McLean C A, Laidlaw J D, Brownbill D S, Gonzales M F
Department of Anatomical Pathology, Royal Melbourne Hospital, Australia.
J Neurosurg. 1990 Dec;73(6):946-50. doi: 10.3171/jns.1990.73.6.0946.
A 75-year-old man presented with a right cerebellopontine angle tumor 11 months after complete macroscopic resection of a right acoustic neurilemoma. Histological examination of the recurrent tumor showed a malignant spindle-cell neoplasm with positive staining for S-100 protein. The patient had no stigmata of von Recklinghausen's disease. It is proposed that this recurrence represents progression from a benign to a malignant acoustic nerve-sheath tumor, an event that is extremely rare outside the clinicopathological context of neurofibromatosis.
一名75岁男性在右侧听神经鞘瘤完全肉眼切除术后11个月出现右小脑桥脑角肿瘤。复发性肿瘤的组织学检查显示为恶性梭形细胞瘤，S-100蛋白染色阳性。该患者没有冯·雷克林豪森病的体征。据推测，这种复发代表了从良性听神经鞘瘤向恶性肿瘤的进展，这一事件在神经纤维瘤病的临床病理背景之外极为罕见。
