Kudo M, Matsumoto M, Terao H
Arch Pathol Lab Med. 1983 Jun;107(6):293-7.
A malignant nerve sheath tumor of the acoustic nerve was found in a 54-year-old man whose right acoustic nerve signs had shown gradual worsening during the previous five years. No stigmata of von Recklinghausen's disease were noted. The tumor at autopsy extensively involved the brain stem, cerebellar hemisphere, tentorium of cerebellum, and cerebral occipitotemporal lobe on the right side. Histologically, the tumor was characterized by extreme hypercellularity, pleomorphism, and high mitotic activity. Ultrastructurally, there was an external lamina around the interdigitated cytoplasm of the tumor cells. Long-spacing collagens and junctional devices were also noted. This case is, to our knowledge, the first reported of a malignant nerve sheath tumor in the acoustic nerve.
在一名54岁男性中发现了听神经恶性神经鞘瘤，该患者右听神经体征在过去五年中逐渐恶化。未发现冯雷克林霍增氏病的体征。尸检时肿瘤广泛累及脑干、小脑半球、小脑幕及右侧大脑枕颞叶。组织学上，肿瘤的特征是细胞极度增多、多形性和高有丝分裂活性。超微结构上，肿瘤细胞相互交错的细胞质周围有一层外板。还发现了长间距胶原纤维和连接装置。据我们所知，该病例是首次报道的听神经恶性神经鞘瘤。
