Department of Molecular Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.
Atherosclerosis. 2012 Apr;221(2):458-60. doi: 10.1016/j.atherosclerosis.2012.01.003. Epub 2012 Jan 20.
Recent genome-wide association studies have identified polymorphisms of lymphotoxin-α (LTA), galectin-2 (LGALS2), and proteasome subunit a type 6 (PSMA6) genes as genetic risk factors for myocardial infarction (MI). However, their effects on coronary atherosclerosis, an intermediate phenotype of MI, remain largely unknown.
We investigated the correlation between polymorphisms of the LTA, LGALS2, and PSMA6 genes and the severity of pathological coronary stenosis index (CSI) and MI in 1503 consecutive autopsy cases of Japanese elderly patients.
The polymorphisms LTA rs1041981 and LGALS2 rs7291467 were associated with CSI with odds ratios of 1.54 (95% CI, 1.17-2.01; AA+CA over CC) and 1.62 (95% CI, 1.11-2.37; TT over CC+CT), respectively. PSMA6 rs1048990 was not associated with CSI. None of the SNPs was associated with MI in our sample.
Our findings indicate that the LTA and LGALS2 polymorphisms affect the subclinical phenotype of the coronary artery, which predisposes to the incidence of MI.
最近的全基因组关联研究已经确定了淋巴毒素-α（LTA）、半乳糖凝集素-2（LGALS2）和蛋白酶体亚单位 a 类型 6（PSMA6）基因的多态性是心肌梗死（MI）的遗传风险因素。然而，它们对冠状动脉粥样硬化（MI 的中间表型）的影响在很大程度上仍然未知。
我们研究了 LTA、LGALS2 和 PSMA6 基因的多态性与 1503 例连续尸检的日本老年患者的病理性冠状动脉狭窄指数（CSI）和 MI 严重程度之间的相关性。
LTA rs1041981 和 LGALS2 rs7291467 多态性与 CSI 相关，优势比分别为 1.54（95%CI，1.17-2.01；AA+CA 超过 CC）和 1.62（95%CI，1.11-2.37；TT 超过 CC+CT）。PSMA6 rs1048990 与 CSI 无关。在我们的样本中，没有一个 SNP 与 MI 相关。
我们的研究结果表明，LTA 和 LGALS2 多态性影响冠状动脉的亚临床表型，从而增加 MI 的发病风险。
