Key Laboratory for Clinical Cardiovascular Genetics, Ministry of Education, Sino-German Laboratory for Molecular Medicine, Cardiovascular Institute, Fu Wai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, 167 Beilishi Road, Beijing 100037, PR China.
Atherosclerosis. 2010 Feb;208(2):433-6. doi: 10.1016/j.atherosclerosis.2009.08.014. Epub 2009 Aug 14.
Previous case-control studies suggested the single nucleotide polymorphisms of lymphotoxin-alpha (LTA) gene and galectin-2 (LGASL2) gene are associated with coronary artery disease and myocardial infarction. However, other studies did not confirm this relationship. The objective was to assess the relationship of LTA gene, LGALS2 gene and coronary artery disease, using a meta-analysis.
Databases, including PubMed, EMbase, CBM and CNKI, were searched to get the genetic association studies. Data were extracted by two authors and pooled odds ratio (OR) and 95% confidence interval (CI) were calculated.
The meta-analysis included 20640 (LTA-A252G) and 10552 (LGALS2-C3279T) cases, 15388 (A252G) and 10545 (C3279T) controls. The pooled OR of 252G was 1.02 (95%CI: 0.97-1.07) compared to wild type allele in dominant model, and was 1.00 (95%CI: 0.94-1.07) in recessive model. The pooled OR of 3279T was 0.95 (95%CI: 0.89-1.01) compared to wild type allele in dominant model, and was 0.89 (95%CI: 0.78-1.00) in recessive model. None of the polymorphisms was found to associate with coronary artery disease.
In present study, the LTA gene and LGALS2-C3279T are not associated with coronary artery disease.
先前的病例对照研究表明，淋巴毒素-α（LTA）基因和半乳糖凝集素-2（LGASL2）基因的单核苷酸多态性与冠心病和心肌梗死有关。然而，其他研究并未证实这种关系。本研究旨在通过荟萃分析评估 LTA 基因、LGALS2 基因与冠心病的关系。
检索包括 PubMed、EMbase、CBM 和 CNKI 在内的数据库，获取遗传关联研究。由两名作者提取数据，并计算合并优势比（OR）和 95%置信区间（CI）。
荟萃分析纳入了 20640 例（LTA-A252G）和 10552 例（LGALS2-C3279T）病例，15388 例（A252G）和 10545 例（C3279T）对照。在显性模型中，与野生型等位基因相比，252G 的合并 OR 为 1.02（95%CI：0.97-1.07），在隐性模型中为 1.00（95%CI：0.94-1.07）。与野生型等位基因相比，3279T 的合并 OR 在显性模型中为 0.95（95%CI：0.89-1.01），在隐性模型中为 0.89（95%CI：0.78-1.00）。未发现任何多态性与冠心病相关。
本研究中，LTA 基因和 LGALS2-C3279T 与冠心病无关。
