性与单一 DM 结构域：对性调节、进化和可塑性的认识。
Sex and the singular DM domain: insights into sexual regulation, evolution and plasticity.
机构信息
Department of Genetics, Cell Biology, and Development, University of Minnesota, 6-160 Jackson Hall, 321 Church Street SE, Minneapolis, Minnesota 55455, USA.
出版信息
Nat Rev Genet. 2012 Feb 7;13(3):163-74. doi: 10.1038/nrg3161.
Abstract
Most animals reproduce sexually, but the genetic and molecular mechanisms that determine the eventual sex of each embryo vary remarkably. DM domain genes, which are related to the insect gene doublesex, are integral to sexual development and its evolution in many metazoans. Recent studies of DM domain genes reveal mechanisms by which new sexual dimorphisms have evolved in invertebrates and show that one gene, Dmrt1, was central to multiple evolutionary transitions between sex-determining mechanisms in vertebrates. In addition, Dmrt1 coordinates a surprising array of distinct cell fate decisions in the mammalian gonad and even guards against transdifferentiation of male cells into female cells in the adult testis.
摘要
大多数动物通过有性繁殖来繁殖后代，但决定每个胚胎最终性别的遗传和分子机制差异很大。DM 结构域基因与昆虫基因 doublesex 有关，是许多后生动物性发育及其进化的重要组成部分。最近对 DM 结构域基因的研究揭示了新的性二态性在无脊椎动物中进化的机制，并表明一个基因 Dmrt1 是脊椎动物性别决定机制之间多次进化转变的核心。此外，Dmrt1 协调了哺乳动物性腺中一系列惊人的不同细胞命运决定，甚至可以防止成年睾丸中雄性细胞向雌性细胞的转分化。
相似文献
1
Sex and the singular DM domain: insights into sexual regulation, evolution and plasticity.性与单一 DM 结构域：对性调节、进化和可塑性的认识。
Nat Rev Genet. 2012 Feb 7;13(3):163-74. doi: 10.1038/nrg3161.
2
Expression of Dmrt1 in the genital ridge of mouse and chicken embryos suggests a role in vertebrate sexual development.Dmrt1在小鼠和鸡胚胎生殖嵴中的表达表明其在脊椎动物性发育中发挥作用。
Dev Biol. 1999 Nov 15;215(2):208-20. doi: 10.1006/dbio.1999.9461.
3
Sexual cell-fate reprogramming in the ovary by DMRT1.DMRT1介导的卵巢中性细胞命运重编程
Curr Biol. 2015 Mar 16;25(6):764-771. doi: 10.1016/j.cub.2015.01.034. Epub 2015 Feb 12.
4
Female-to-male sex reversal in mice caused by transgenic overexpression of Dmrt1.由Dmrt1转基因过表达导致的小鼠雌性向雄性性反转。
Development. 2015 Mar 15;142(6):1083-8. doi: 10.1242/dev.122184. Epub 2015 Feb 27.
5
DMRT1 prevents female reprogramming in the postnatal mammalian testis.DMRT1 可防止产后哺乳动物睾丸中的雌性重编程。
Nature. 2011 Jul 20;476(7358):101-4. doi: 10.1038/nature10239.
6
DMRT genes in vertebrate gametogenesis.脊椎动物配子发生中的 DMRT 基因。
Curr Top Dev Biol. 2013;102:327-56. doi: 10.1016/B978-0-12-416024-8.00012-X.
7
Opposite roles of DMRT1 and its W-linked paralogue, DM-W, in sexual dimorphism of Xenopus laevis: implications of a ZZ/ZW-type sex-determining system.DMRT1 及其 W 连锁同源物 DM-W 在非洲爪蟾性二型中的相反作用：ZZ/ZW 型性别决定系统的意义。
Development. 2010 Aug 1;137(15):2519-26. doi: 10.1242/dev.048751. Epub 2010 Jun 23.
8
Germ cells are not the primary factor for sexual fate determination in goldfish.生殖细胞不是金鱼性别的决定因素。
Dev Biol. 2012 Oct 1;370(1):98-109. doi: 10.1016/j.ydbio.2012.07.010. Epub 2012 Jul 21.
9
Sexually dimorphic expression of multiple doublesex-related genes in the embryonic mouse gonad.胚胎期小鼠性腺中多个与双性基因相关基因的性别二态性表达。
Gene Expr Patterns. 2003 Mar;3(1):77-82. doi: 10.1016/s1567-133x(02)00071-6.
10
Molecular evolution of vertebrate sex-determining genes.脊椎动物性别决定基因的分子进化。
Chromosome Res. 2012 Jan;20(1):139-51. doi: 10.1007/s10577-011-9265-9.
引用本文的文献
1
The Interaction of DMRTA2 with HSP90β Inhibits p53 Ubiquitination and Activates the p53 Pathway to Suppress the Malignant Progression of Non-Small-Cell Lung Cancer.DMRTA2与HSP90β的相互作用抑制p53泛素化并激活p53通路以抑制非小细胞肺癌的恶性进展。
Curr Issues Mol Biol. 2025 Jun 28;47(7):497. doi: 10.3390/cimb47070497.
2
Decoding sexual dimorphism of the sex-shared nervous system at single-neuron resolution.在单神经元分辨率下解析性别共享神经系统的性二态性。
bioRxiv. 2025 May 8:2024.12.27.630541. doi: 10.1101/2024.12.27.630541.
3
Decoding sexual dimorphism of the sex-shared nervous system at single-neuron resolution.在单神经元分辨率下解码性别共享神经系统的性二态性。
Sci Adv. 2025 Jul 11;11(28):eadv9106. doi: 10.1126/sciadv.adv9106.
4
Roles of a Y-Linked iDmrt1 Paralogue and Insulin-like Androgenic Gland Hormone in Sexual Development in the Tropical Rock Lobster, .Y连锁iDmrt1旁系同源基因和胰岛素样雄性腺激素在热带岩龙虾性发育中的作用
Int J Mol Sci. 2025 May 27;26(11):5149. doi: 10.3390/ijms26115149.
5
Deciphering the genetic basis of sex differentiation in silver-lipped pearl oyster ( ) based on integrative transcriptomic analysis.基于综合转录组分析解析银唇珠母贝性别分化的遗传基础。 （括号内原文缺失具体物种名）
Zool Res. 2025 Mar 18;46(2):285-300. doi: 10.24272/j.issn.2095-8137.2024.266.
6
Experience-dependent, sexually dimorphic synaptic connectivity defined by sex-specific cadherin expression.性别特异性钙黏蛋白表达决定的经验依赖性、性别二态性突触连接
Sci Adv. 2024 Nov 15;10(46):eadq9183. doi: 10.1126/sciadv.adq9183. Epub 2024 Nov 13.
7
Dedicated developmental programing for group-supporting behaviors in eusocial honeybees.专门针对社会性蜜蜂的群体支持行为进行的发展规划。
Sci Adv. 2024 Nov;10(44):eadp3953. doi: 10.1126/sciadv.adp3953. Epub 2024 Nov 1.
8
Diversity of transactivation regions of DMRT1 in vertebrates.脊椎动物 DMRT1 转录激活区的多样性。
Mol Biol Rep. 2024 Oct 21;51(1):1077. doi: 10.1007/s11033-024-10006-9.
9
Gonadal Development and Differentiation of Hybrid F Line of (♀) × (♂).杂种 F 系（♀）×（♂）的性腺发育和分化。
Int J Mol Sci. 2024 Sep 30;25(19):10566. doi: 10.3390/ijms251910566.
10
Sexual dimorphism in the tardigrade Paramacrobiotus metropolitanus transcriptome.缓步动物大都会副棘影熊虫转录组中的性别二态性
Zoological Lett. 2024 Jun 20;10(1):11. doi: 10.1186/s40851-024-00233-0.
本文引用的文献
1
Dmrt1 mutation causes a male-to-female sex reversal after the sex determination by Dmy in the medaka.Dmrt1 突变导致在性决定基因 Dmy 作用后，青鳉的雄性个体向雌性个体发生性反转。
Chromosome Res. 2012 Jan;20(1):163-76. doi: 10.1007/s10577-011-9264-x.
2
Multiple doublesex-related genes specify critical cell fates in a C. elegans male neural circuit.多个与 doublesex 相关的基因在秀丽隐杆线虫雄性神经回路中指定关键的细胞命运。
PLoS One. 2011;6(11):e26811. doi: 10.1371/journal.pone.0026811. Epub 2011 Nov 1.
3
Testicular dmrt1 is involved in the sexual fate of the ovotestis in the protandrous black porgy.睾丸 dmrt1 参与了性早熟黑鲷的卵睾的性命运。
Biol Reprod. 2012 Feb 14;86(2):41. doi: 10.1095/biolreprod.111.095695. Print 2012 Feb.
4
Rapid and efficient reprogramming of somatic cells to induced pluripotent stem cells by retinoic acid receptor gamma and liver receptor homolog 1.维甲酸受体γ和肝受体同源物 1 快速高效地将体细胞重编程为诱导多能干细胞。
Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18283-8. doi: 10.1073/pnas.1100893108. Epub 2011 Oct 11.
5
An SNP-Based Linkage Map for Zebrafish Reveals Sex Determination Loci.基于单核苷酸多态性的斑马鱼连锁图谱揭示性别决定位点。
G3 (Bethesda). 2011 Jun 1;1(1):3-9. doi: 10.1534/g3.111.000190.
6
Evolution of sex-specific traits through changes in HOX-dependent doublesex expression.通过改变 HOX 依赖性 doublesex 表达来实现性别特异性特征的进化。
PLoS Biol. 2011 Aug;9(8):e1001131. doi: 10.1371/journal.pbio.1001131. Epub 2011 Aug 23.
7
DMRT1 prevents female reprogramming in the postnatal mammalian testis.DMRT1 可防止产后哺乳动物睾丸中的雌性重编程。
Nature. 2011 Jul 20;476(7358):101-4. doi: 10.1038/nature10239.
8
Antagonistic regulation of Cyp26b1 by transcription factors SOX9/SF1 and FOXL2 during gonadal development in mice.在小鼠的性腺发育过程中，转录因子 SOX9/SF1 和 FOXL2 对 Cyp26b1 进行拮抗调节。
FASEB J. 2011 Oct;25(10):3561-9. doi: 10.1096/fj.11-184333. Epub 2011 Jul 14.
9
Sexually dimorphic regulation of the Wingless morphogen controls sex-specific segment number in Drosophila.性二态调节 Wnt 形态发生素控制果蝇的性别特异性体节数。
Proc Natl Acad Sci U S A. 2011 Jul 5;108(27):11139-44. doi: 10.1073/pnas.1108431108. Epub 2011 Jun 20.
10
Direct targets of the D. melanogaster DSXF protein and the evolution of sexual development.黑腹果蝇 DSXF 蛋白的直接靶标与性发育的进化。
Development. 2011 Jul;138(13):2761-71. doi: 10.1242/dev.065227.
Zotero 插件