固有免疫在慢性鼻-鼻窦炎发病机制中的作用：进展与新途径。
Role of innate immunity in the pathogenesis of chronic rhinosinusitis: progress and new avenues.
机构信息
Department of Otorhinolaryngology, Academic Medical Center, Amsterdam, The Netherlands.
出版信息
Curr Allergy Asthma Rep. 2012 Apr;12(2):120-6. doi: 10.1007/s11882-012-0249-4.
Abstract
Chronic rhinosinusitis is a heterogeneous and multifactorial disease with unknown etiology. Aberrant responses to microorganisms have been suggested to play a role in the pathophysiology of the disease. Research has focused on the presence, detection, response to, and eradication of these potential threats. Main topics seem to center on the contribution of structural cells such as epithelium and fibroblasts, on the consequences of activation of pattern-recognition receptors, and on the role of antimicrobial agents. This research should be viewed not only in the light of a comparison between healthy and diseased individuals, but also in a comparison between patients who do or do not respond to treatment. New players that could play a role in the pathophysiology seem to surface at regular intervals, adding to our understanding (and the complexity) of the disease and opening new avenues that may help fight this incapacitating disease.
摘要
慢性鼻-鼻窦炎是一种具有未知病因的异质性和多因素疾病。目前认为，对微生物的异常反应在疾病的病理生理学中起作用。研究主要集中在这些潜在威胁的存在、检测、反应和消除上。主要研究内容似乎集中在结构细胞（如上皮细胞和成纤维细胞）的作用、模式识别受体激活的后果以及抗菌药物的作用上。这项研究不仅应该着眼于健康个体和患病个体之间的比较，还应该着眼于对治疗有反应和无反应的患者之间的比较。新的可能在病理生理学中发挥作用的参与者定期出现，这增加了我们对这种疾病的理解（和复杂性），并开辟了新的途径，可能有助于对抗这种使人丧失能力的疾病。
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