Department of Paediatrics, Capital and Coast District Health Board, Wellington, New Zealand.
Pediatrics. 2012 Mar;129(3):e817-20. doi: 10.1542/peds.2011-0634. Epub 2012 Feb 6.
Resistance to thyroid hormone is an uncommon problem, which has rarely been associated with thyroid dysgenesis. We report a case with both thyroid gland ectopy and resistance to thyroid hormone and, thus, a reduced capacity to produce and respond to thyroid hormone. The patient presented at 2 years of age with developmental delay, dysmorphic features, and elevation in both thyroxine and thyrotropin. We document her response to therapy with thyroxine, with particular regard to her growth and development. Persistent elevation of thyrotropin is commonly recognized during treatment of congenital hypothyroidism. Resistance to thyroid hormone may be an important additional diagnosis to consider in cases where thyrotropin remains persistently elevated.
抗甲状腺激素是一种不常见的问题，很少与甲状腺发育不良有关。我们报告了一例既有甲状腺异位又有抗甲状腺激素的病例，因此甲状腺激素的产生和反应能力降低。该患者在 2 岁时出现发育迟缓、畸形特征以及甲状腺素和促甲状腺素升高。我们记录了她对甲状腺素治疗的反应，特别关注她的生长发育情况。在治疗先天性甲状腺功能减退症期间，促甲状腺素持续升高是常见的。在促甲状腺素持续升高的情况下，应考虑抗甲状腺激素作为一个重要的附加诊断。
