Schuster Philipp, Boscheinen Jan Bernardin, Tennert Karin, Schmidt Barbara
Institute of Clinical and Molecular Virology, German National Reference Centre for Retroviruses, Friedrich-Alexander-Universität Erlangen-Nürnberg, Schlossgarten 4, 91054 Erlangen, Germany.
Adv Virol. 2011;2011:679271. doi: 10.1155/2011/679271. Epub 2011 Mar 31.
In 1999, two independent groups identified plasmacytoid dendritic cells (PDC) as major type I interferon- (IFN-) producing cells in the blood. Since then, evidence is accumulating that PDC are a multifunctional cell population effectively coordinating innate and adaptive immune responses. This paper focuses on the role of different immune cells and their interactions in the surveillance of alpha herpes virus infections, summarizes current knowledge on PDC surface receptors and their role in direct cell-cell contacts, and develops a risk factor model for the clinical implications of herpes simplex and varicella zoster virus reactivation. Data from studies involving knockout mice and cell-depletion experiments as well as human studies converge into a "spider web", in which the direct and indirect crosstalk between many cell populations tightly controls acute, latent, and recurrent alpha herpes virus infections. Notably, cells involved in innate immune regulations appear to shape adaptive immune responses more extensively than previously thought.
1999年，两个独立的研究小组将浆细胞样树突状细胞（PDC）确定为血液中主要产生I型干扰素（IFN）的细胞。从那时起，越来越多的证据表明，PDC是一个多功能细胞群体，可有效协调先天性和适应性免疫反应。本文重点关注不同免疫细胞在α疱疹病毒感染监测中的作用及其相互作用，总结了关于PDC表面受体及其在直接细胞间接触中的作用的现有知识，并建立了一个危险因素模型，用于评估单纯疱疹病毒和水痘带状疱疹病毒再激活的临床意义。来自涉及基因敲除小鼠和细胞耗竭实验的研究数据以及人体研究数据汇聚成一个“蜘蛛网”，其中许多细胞群体之间的直接和间接串扰紧密控制着急性、潜伏性和复发性α疱疹病毒感染。值得注意的是，参与先天性免疫调节的细胞似乎比以前认为的更广泛地塑造适应性免疫反应。
