Taghavi Seyed Alireza, Tabibi Manouchehr, Eshraghian Ahad, Keyvani Hossein, Eshraghian Hamed
Gastroenterohepatology Research Center, Shiraz University of Medical Science, Shiraz, IR Iran.
Hepat Mon. 2010 Fall;10(4):294-7. Epub 2010 Dec 1.
To investigate the prevalence and pattern of PC and BCP mutations and their clinical significance in patients with genotype D chronic hepatitis B infection in the Fars province of southern Iran.
From January 2007 to March 2008, we evaluated 44 patients with chronic hepatitis B infection who were referred to our hepatology clinics affiliated with the Shiraz University of Medical Science. All Patients were HBeAg Negative and HBeAb positive. Basal core promoter and precore mutations in these patients were evaluated with clinical phenotype and laboratory tests.
The mean age of the patients was 37.21 ± 10.54 years. Twenty-seven patients (61.4%) had no mutations, whereas 17 patients (38.6%) had mutations in the precore or basal core promoter regions or both. The mean serum ALT level in mutation-free patients was 59.74 ± 55.86 IUL, whereas patients with PC and BCP mutations had a mean serum ALT level of 71.35 ± 59.49 IUL. The mean serum AST level in patients with mutations was higher than for patients without mutations (59.53 ± 41.35 IUL vs. 40.65 ± 25.21 IUL, respectively). There was no statistically significant difference between the mutation and mutation-free groups in terms of age, sex, and liver enzyme levels (P > 0.05). Fourteen of the 44 patients (31.8%) had mutations in the precore region (G 1896A). 17 patients (38.6%) had mutations in basal core promoter region.
This study revealed a high prevalence of precore and basal core promoter mutations in southern Iran. Although no statistically significant difference was noted in liver enzymes, patients with mutations had higher liver enzymes in comparison with mutation-free patients.
调查伊朗南部法尔斯省D基因型慢性乙型肝炎感染患者中前核心（PC）和基本核心启动子（BCP）突变的发生率、模式及其临床意义。
2007年1月至2008年3月，我们评估了44例转诊至设拉子医科大学附属肝病诊所的慢性乙型肝炎感染患者。所有患者HBeAg阴性且HBeAb阳性。通过临床表型和实验室检查评估这些患者的基本核心启动子和前核心突变。
患者的平均年龄为37.21±10.54岁。27例患者（61.4%）无突变，而17例患者（38.6%）在前核心区或基本核心启动子区或两者均有突变。无突变患者的平均血清ALT水平为59.74±55.86 IU/L，而有PC和BCP突变的患者平均血清ALT水平为71.35±59.49 IU/L。有突变患者的平均血清AST水平高于无突变患者（分别为59.53±41.35 IU/L和40.65±25.21 IU/L）。在年龄、性别和肝酶水平方面，突变组与无突变组之间无统计学显著差异（P>0.05）。44例患者中有14例（31.8%）在前核心区（G1896A）有突变。17例患者（38.6%）在基本核心启动子区有突变。
本研究显示伊朗南部前核心和基本核心启动子突变的发生率较高。虽然在肝酶方面未观察到统计学显著差异，但与无突变患者相比，有突变患者的肝酶水平更高。
