Feng Xiao-Tao, Qin Can-Bin, Leng Jing, Tang Qian-Li, Shi Hong, Zhai Lin-Na, Li Shuang-Lei
Guangxi Scientific Experimental Center for Traditional Chinese Medicine, Guangxi Traditional Chinese Medical University, Nanning, China.
Biosci Biotechnol Biochem. 2012;76(2):257-63. doi: 10.1271/bbb.110568. Epub 2012 Feb 7.
The nitric-oxide (NO)-cyclic-guanosine-monophosphate (cGMP) pathway plays a key role in penile erection. Erectile dysfunction (ED) is a complication in male diabetic patients that impacts their quality of 1ife. Recently, Yidiyin, a Chinese herbal decoction, is used to treat diabetic ED, but convincing evidence is lacking, and the potential mechanisms remain uncertain. In the study, diabetic ED patients had low scores on international index of erectile function-5 (IIEF-5), and administration of Yidiyin and hypoglycemic drugs for 16 weeks ameliorated patients' scores on IIEF-5 more than the hypoglycemic drug alone. Moreover, streptozotocin-induced diabetes severely impaired rats' erectile function and the activity of the NO-cGMP pathway in the corpora cavernosum, and treatment with Yidiyin for 4 weeks obviously increased the rats' erectile function, remarkably enhanced the activity of nitric oxide synthase (NOS), and elevated the contents of NO and cGMP. Our findings indicate that Yidiyin improves diabetic ED probably by enhancing the NO-cGMP pathway.
一氧化氮（NO）-环磷酸鸟苷（cGMP）通路在阴茎勃起中起关键作用。勃起功能障碍（ED）是男性糖尿病患者的一种并发症，会影响他们的生活质量。最近，中药汤剂益地饮被用于治疗糖尿病性ED，但缺乏令人信服的证据，其潜在机制仍不确定。在该研究中，糖尿病性ED患者的国际勃起功能指数-5（IIEF-5）得分较低，给予益地饮和降糖药物治疗16周后，患者的IIEF-5得分改善程度超过单纯使用降糖药物。此外，链脲佐菌素诱导的糖尿病严重损害了大鼠的勃起功能以及海绵体中NO-cGMP通路的活性，用益地饮治疗4周明显提高了大鼠的勃起功能，显著增强了一氧化氮合酶（NOS）的活性，并提高了NO和cGMP的含量。我们的研究结果表明，益地饮可能通过增强NO-cGMP通路来改善糖尿病性ED。
