Division of Urology, Department of Surgery, Far Eastern Memorial Hospital, Ban Ciao, Taiwan.
BJU Int. 2012 Aug;110(4):550-4. doi: 10.1111/j.1464-410X.2012.10929.x. Epub 2012 Feb 7.
Study Type - Symptom prevalence (case control). Level of Evidence 2b. What's known on the subject? and What does the study add? Associations are well established between intestinal infection/inflammation or inflammatory bowel diseases and colorectal cancer (CRC). Our study found an association between CRC and previously diagnosed chronic prostatitis/chronic pelvic pain syndrome. Patients with CRC had a 1.45-fold higher risk of having a previous diagnosis of chronic prostatitis/chronic pelvic pain syndrome than controls. This phenomenon was found to be more prominent in subjects younger than 60 years.
• To estimate the association between chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and colorectal cancer (CRC) using a nationwide population-based data set.
• This case-control study used data sourced from the Taiwan Longitudinal Health Insurance Database. • The cases comprised 2899 patients with CRC and 14 995 randomly selected subjects as controls. • We used conditional logistic regression to examine the association between CRC and previous diagnosis of CP/CPPS.
• Of the sampled patients, 531(3.05%) had been diagnosed with CP/CPPS before the index date, with 123 (4.24% of the patients with CRC) coming from the cases and 408 individuals (2.81% of patients without CRC) coming from the controls. • Conditional logistic regression analysis revealed that cases were more likely to have CP/CPPS than controls (odds ratio 1.45, 95% CI 1.17-1.79, P < 0.001) after adjusting for the monthly income, geographic location, urbanization level, hypertension, diabetes, renal disease, obesity and cystic kidney disease. • In subgroup analysis, we found the magnitude of the association to be higher in subjects younger than 60 years (age 40-49, odds ratio 2.01; 95% CI 2.04-3.58 and aged 50-59, 2.40, 95% CI 1.48-3.87, both P < 0.001) than among other age groups.
• We conclude that CP/CPPS patients are at higher risk for CRC, especially in males under 60 years of age.
• 使用基于全国人群的数据集估计慢性前列腺炎/慢性骨盆疼痛综合征（CP/CPPS）与结直肠癌（CRC）之间的关联。
• 本病例对照研究使用来自台湾纵向健康保险数据库的数据。• 病例组包括 2899 例 CRC 患者和 14995 名随机选择的对照。• 我们使用条件逻辑回归来检查 CRC 与 CP/CPPS 之前的诊断之间的关联。
• 在抽样患者中，有 531 例（3.05%）在索引日期前被诊断为 CP/CPPS，其中 123 例（CRC 患者的 4.24%）来自病例组，408 例（无 CRC 患者的 2.81%）来自对照组。• 条件逻辑回归分析表明，在调整月收入、地理位置、城市化水平、高血压、糖尿病、肾脏疾病、肥胖和囊性肾病后，病例组比对照组更有可能患有 CP/CPPS（比值比 1.45，95%置信区间 1.17-1.79，P < 0.001）。• 在亚组分析中，我们发现该关联在 60 岁以下的人群中更为显著（40-49 岁，比值比 2.01；95%置信区间 2.04-3.58 和 50-59 岁，2.40，95%置信区间 1.48-3.87，均 P < 0.001）。
• 我们的结论是，CP/CPPS 患者患 CRC 的风险较高，尤其是 60 岁以下的男性。
