Institute of Life Science, the Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing 210096, China.
Sci China Life Sci. 2012 Jan;55(1):27-34. doi: 10.1007/s11427-012-4272-4. Epub 2012 Feb 8.
The Drosophila visual transduction is the fastest known G protein-coupled signaling cascade and has been served as a model for understanding the molecular mechanisms of other G protein-coupled signaling cascades. Numbers of components in visual transduction machinery have been identified. Based on the functional characterization of these genes, a model for Drosophila phototransduction has been outlined, including rhodopsin activation, phosphoinoside signaling, and the opening of TRP and TRPL channels. Recently, the characterization of mutants, showing slow termination, revealed the physiological significance and the mechanism of rapid termination of light response.
果蝇视觉转导是已知最快的 G 蛋白偶联信号级联反应，一直被用作理解其他 G 蛋白偶联信号级联反应分子机制的模型。已经鉴定出视觉转导机械装置中的许多组件。基于这些基因的功能特征，已经概述了果蝇光转导模型，包括视蛋白激活、磷酸肌醇信号转导和 TRP 和 TRPL 通道的打开。最近，对表现出缓慢终止的突变体的特征分析揭示了光反应快速终止的生理意义和机制。
