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本文引用的文献

1
Aspergillus PCR: one step closer to standardization.曲霉 PCR：更接近标准化一步。
J Clin Microbiol. 2010 Apr;48(4):1231-40. doi: 10.1128/JCM.01767-09. Epub 2010 Feb 10.
2
Post-antifungal effect of amphotericin B and voriconazole against germinated Aspergillus fumigatus conidia.两性霉素B和伏立康唑对烟曲霉分生孢子萌发后的抗真菌作用。
J Antimicrob Chemother. 2008 Jun;61(6):1309-11. doi: 10.1093/jac/dkn129. Epub 2008 Mar 26.
3
Fungal infections in recipients of hematopoietic stem cell transplants: results of the SEIFEM B-2004 study--Sorveglianza Epidemiologica Infezioni Fungine Nelle Emopatie Maligne.造血干细胞移植受者的真菌感染：SEIFEM B - 2004研究结果——恶性血液病真菌性感染的流行病学监测
Clin Infect Dis. 2007 Nov 1;45(9):1161-70. doi: 10.1086/522189. Epub 2007 Sep 26.
4
Aspergillus infection in lung transplant patients: incidence and prognosis.肺移植患者的曲霉感染：发病率与预后
Eur J Clin Microbiol Infect Dis. 2007 Dec;26(12):879-86. doi: 10.1007/s10096-007-0376-3.
5
Invasive aspergillosis: epidemiology, diagnosis and management in immunocompromised patients.侵袭性曲霉病：免疫功能低下患者的流行病学、诊断与管理
Drugs. 2007;67(11):1567-601. doi: 10.2165/00003495-200767110-00004.
6
Transcriptome analysis of Aspergillus fumigatus exposed to voriconazole.伏立康唑作用下烟曲霉的转录组分析
Curr Genet. 2006 Jul;50(1):32-44. doi: 10.1007/s00294-006-0073-2. Epub 2006 Apr 19.
7
Characterization of Aspergillus fumigatus mutants with reduced susceptibility to caspofungin.对卡泊芬净敏感性降低的烟曲霉突变体的鉴定
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8
A comparative study of the post-antifungal effect (PAFE) of amphotericin B, triazoles and echinocandins on Aspergillus fumigatus and Candida albicans.两性霉素B、三唑类和棘白菌素对烟曲霉和白色念珠菌的抗真菌后效应（PAFE）的比较研究。
J Antimicrob Chemother. 2004 Feb;53(2):386-9. doi: 10.1093/jac/dkh066. Epub 2004 Jan 16.
9
Invasive aspergillosis in allogeneic stem cell transplant recipients: changes in epidemiology and risk factors.异基因干细胞移植受者中的侵袭性曲霉病：流行病学和危险因素的变化
Blood. 2002 Dec 15;100(13):4358-66. doi: 10.1182/blood-2002-05-1496. Epub 2002 Aug 22.
10
Method for measuring postantifungal effect in Aspergillus species.测量曲霉属真菌抗真菌后效应的方法。
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通过表达谱变化分析监测两性霉素 B、伏立康唑和米卡芬净对烟曲霉的抗真菌活性。

Expression turnover profiling to monitor the antifungal activities of amphotericin B, voriconazole, and micafungin against Aspergillus fumigatus.

机构信息

Public Health Research Institute Center, UMDNJ-New Jersey Medical School, Newark, New Jersey, USA..

出版信息

Antimicrob Agents Chemother. 2012 May;56(5):2770-2. doi: 10.1128/AAC.06163-11. Epub 2012 Feb 6.

DOI:10.1128/AAC.06163-11
PMID:22314535
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3346633/
Abstract

Eight highly expressed candidate genes were selected for mRNA profiling to monitor the transcriptome kinetics of Aspergillus fumigatus strains exposed to antifungal drugs as potential biomarkers of live cells to assess treatment efficacy. Mycelia were treated with fungicidal drugs amphotericin B and voriconazole, as well as the fungistatic drug micafungin. Transcription was monitored at 0, 4, 8, and 24 h posttreatment. The expression turnover profile provides a possible tool to assess antifungal therapy effects.

摘要

选择了 8 个高表达的候选基因进行 mRNA 谱分析，以监测暴露于抗真菌药物的烟曲霉菌株的转录组动力学，作为活细胞的潜在生物标志物来评估治疗效果。用杀真菌药物两性霉素 B 和伏立康唑以及抑菌药物米卡芬净处理菌丝体。在处理后 0、4、8 和 24 小时监测转录。表达周转率谱提供了一种评估抗真菌治疗效果的可能工具。