Oyeyipo I P, Olatunji L A, Akhigbe R E, Arokoyo D S, Soladoye A O
Department of Physiology, College of Medicine, Osun State University, Osogbo, Nigeria.
Niger J Physiol Sci. 2010 Nov 25;25(1):73-9.
The effects of high calcium diet on body weight in OC treated rats are unknown. This study therefore investigated the effect of increasing dietary calcium from 0.9% to 2.5% on body weight, food ingestion, water intake, heart weight index and renal weight index in female Sprague-Dawley rats treated with a combination of OC steroids (ethinyloestradiol + norgestrel). The rats were assigned into three groups of average of 11 rats each; control, OC-treated and OC + Calcium – treated groups and administered orally for 10 weeks. Food and water intake, body weight, cardiac weight index, left ventricular weight index, renal weight index and serum calcium level were determined. The result shows that OC treated rats had significantly lower serum calcium concentration, body weight gain, food, water and calcium intake than those of the control rats. The OC + Calcium – treated rat had significantly higher serum calcium concentration, food, water and calcium intake but significantly lower body weight than those of the OC - treated rats. OC + Calcium - treated rats had significantly higher water intake, calcium intake and significantly lower body weight and food intake when compared with the control rats. Cardiac weight index and renal weight index was comparable in all groups. In conclusion, combined OC-induced reduction in weight gain might be associated with inhibition of the feeding center and consequent inhibition of the thirst center. Co-administration of dietary calcium augmented the reduction in weight gain seen in OC-treated rats probably by further suppression of the feeding and thirst centers.
高钙饮食对接受口服避孕药（OC）治疗的大鼠体重的影响尚不清楚。因此，本研究调查了将雌性斯普拉格-道利大鼠的饮食钙含量从0.9%提高到2.5%对其体重、食物摄入量、饮水量、心脏重量指数和肾脏重量指数的影响，这些大鼠接受了OC类固醇（炔雌醇+炔诺孕酮）联合治疗。将大鼠分为三组，每组平均11只；对照组、OC治疗组和OC+钙治疗组，并进行10周的口服给药。测定食物和水的摄入量、体重、心脏重量指数、左心室重量指数、肾脏重量指数和血清钙水平。结果显示，与对照组大鼠相比，接受OC治疗的大鼠血清钙浓度、体重增加、食物、水和钙的摄入量显著降低。与接受OC治疗的大鼠相比，接受OC+钙治疗的大鼠血清钙浓度、食物、水和钙的摄入量显著更高，但体重显著更低。与对照组大鼠相比，接受OC+钙治疗的大鼠饮水量、钙摄入量显著更高，体重和食物摄入量显著更低。所有组的心脏重量指数和肾脏重量指数相当。总之，联合使用OC导致体重增加减少可能与抑制摄食中枢以及随之而来的对渴觉中枢的抑制有关。饮食中补充钙可能通过进一步抑制摄食和渴觉中枢，增强了接受OC治疗的大鼠体重增加的减少。
