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Gag precursors of HIV and SIV are cleaved into six proteins found in the mature virions.

作者信息

Henderson L E, Sowder R C, Copeland T D, Oroszlan S, Benveniste R E

机构信息

Program Resources, Inc., Frederick, MD.

出版信息

J Med Primatol. 1990;19(3-4):411-9.

PMID:2231692
Abstract

During retroviral maturation gag precursors are proteolytically cleaved to mature gag proteins. The number of mature gag proteins and their order in the gag precursors of HIV-I3B, SIVMne (captive macaque isolate), and SIVCat (wild mangabey isolate) has been determined by N-terminal amino acid sequence analysis of mature gag proteins and alignment with predicted sequences of homologous gag precursors. For HIV-1 and SIVs maturation proteolysis results in six gag proteins and the gag precursor cleavage pattern is distinctive and different from cleavage patterns for all other known retroviruses.

摘要

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