Clark W G
Pharmacol Biochem Behav. 1979 Apr;10(4):609-13. doi: 10.1016/0091-3057(79)90241-7.
Of the effects of morphine and endogenous opioid peptides on thermoregulation, the one which is most likely to be of physiologic significance is hyperthermia. This increase in body temperature is the result of coordinated changes in both physiological and behavioral thermoregulatory activities and, like fever, reflects an increase in the level about which body temperature is regulated. Morphine, endogenous opioid peptides and other opioids such as pentazocine all cause hyperthermia, but the considerable variation in the dose of naloxone required to antagonize the different agonists indicates that more than one type of opiate receptor is involved in these pharmacologic responses. The minimal effect of naloxone and naltrexone on normal body temperature and on pyrogen-induced fever indicates that endogenous opioid peptides are unlikely to act physiologically via stimulation of receptors specifically sensitive to morphine. However, methionine-enkephalin is less readily antagonized by naloxone and could have a physiologic role in thermoregulation through stimulation of another type of opiate receptor.
在吗啡和内源性阿片肽对体温调节的作用中，最可能具有生理意义的是体温过高。体温升高是生理和行为体温调节活动协同变化的结果，并且与发热一样，反映了体温调节设定点的升高。吗啡、内源性阿片肽以及其他阿片类药物（如喷他佐辛）都会导致体温过高，但拮抗不同激动剂所需纳洛酮剂量的显著差异表明，这些药理反应涉及不止一种类型的阿片受体。纳洛酮和纳曲酮对正常体温和热原诱导发热的影响极小，这表明内源性阿片肽不太可能通过刺激对吗啡特异性敏感的受体发挥生理作用。然而，甲硫氨酸脑啡肽较难被纳洛酮拮抗，可能通过刺激另一种类型的阿片受体在体温调节中发挥生理作用。
