Paillusson S, Lebouvier T, Pouclet H, Coron E, Bruley des Varannes S, Damier P, Neunlist M, Derkinderen P
Inserm U913, CHU de Nantes, 1, place Alexis-Ricordeau, 44093 Nantes, France.
Rev Med Interne. 2012 Jun;33(6):335-8. doi: 10.1016/j.revmed.2012.01.004. Epub 2012 Feb 6.
It has become increasingly evident over the last years that Parkinson's disease is a multicentric neurodegenerative disease that affects several neuronal structures outside the substantia nigra, among which is the enteric nervous system. The aims of the present article are to discuss the role of the enteric nervous system lesions in pathology spreading (Braak's hypothesis) and in the gastrointestinal dysfunction encountered in Parkinson's disease. Owing to its accessibility to biopsies, we further discuss the use of the enteric nervous system as an original source of biomarker in Parkinson's disease.
在过去几年中，越来越明显的是，帕金森病是一种多中心神经退行性疾病，它会影响黑质以外的几个神经元结构，其中包括肠神经系统。本文的目的是讨论肠神经系统病变在病理传播（Braak假说）以及帕金森病中出现的胃肠功能障碍中的作用。由于其易于进行活检，我们还将讨论将肠神经系统用作帕金森病生物标志物原始来源的用途。
