Laboratoire de Bioénergétique Fondamentale et Appliquée U1055 INSERM, Université Joseph Fourier, BP 53 38041 Grenoble cedex 9, France.
J Bioenerg Biomembr. 2012 Feb;44(1):189-97. doi: 10.1007/s10863-012-9424-5.
ATAD3 (ATPase family AAA Domain-containing protein 3) is a mitochondrial membrane bound ATPase whose function has not yet been discovered but its role is essential for embryonic development. The ATAD3 gene has existed since the pluri-cellular organisms with specialized tissues and has remained unique until vertebrates. In primates and human, two other genes have appeared (called ATAD3B and ATAD3C versus ATAD3A the ancestral gene). ATAD3 knock-down in different non-transformed cell lines is associated with drastic changes in the mitochondrial network, inhibition of proliferation and modification of the functional interactions between mitochondria and endoplasmic reticulum. However, the analysis of the cellular properties of ATAD3A and ATAD3B in different human cancer cell lines shows on the contrary that they can present anti-proliferative and chemoresistant properties. ATAD3 may therefore be implicated in an unknown but essential and growth-linked mitochondrial function existing since pluri-cellular organization and involved in tumorigenesis.
ATAD3（ATPase 家族 AAA 结构域包含蛋白 3）是一种定位于线粒体膜的 ATP 酶，其功能尚未被发现，但它的作用对于胚胎发育至关重要。ATAD3 基因自具有特化组织的多细胞生物开始就已经存在，并一直保持独特性，直到出现脊椎动物。在灵长类动物和人类中，又出现了另外两个基因（称为 ATAD3B 和 ATAD3C，而相对于原始基因 ATAD3A）。在不同的非转化细胞系中敲低 ATAD3 会导致线粒体网络发生剧烈变化、增殖受到抑制以及线粒体和内质网之间的功能相互作用发生改变。然而，对不同人类癌细胞系中 ATAD3A 和 ATAD3B 的细胞特性进行分析表明，它们反而具有抗增殖和化疗耐药性。因此，ATAD3 可能与一种未知但至关重要的、与多细胞组织存在联系的线粒体功能有关，该功能与肿瘤发生有关。
