Jiang Yujie, Liu Xin, Fang Xiaosheng, Wang Xin
Department of Hematology, Provincial Hospital Affiliated to Shandong University, Shandong, China.
Protein Pept Lett. 2009;16(11):1350-9. doi: 10.2174/092986609789353646.
Radioresistance represents a major obstacle to a successful outcome for the treatment of non-Hodgkin's lymphoma (NHL). Here we performed a global differential proteome analysis of the mitochondria in Raji cells exposed to radiation. The results showed that 23 differentially expressed proteins were identified. Furthermore, GAPDH, RECQL4, MKI67, and ATAD3B could serve as potential biomarkers of radioresistance.
放射抗性是非霍奇金淋巴瘤（NHL）治疗取得成功结果的主要障碍。在此，我们对受辐射的Raji细胞中的线粒体进行了全蛋白质组差异分析。结果显示，共鉴定出23种差异表达蛋白。此外，甘油醛-3-磷酸脱氢酶（GAPDH）、RecQ螺旋酶4（RECQL4）、核抗原Ki-67（MKI67）和ATP酶家族AAA结构域成员3B（ATAD3B）可作为放射抗性的潜在生物标志物。
