Department of Rheumatology, University of Foggia Medical School, Foggia, Italy.
Eur J Clin Pharmacol. 2012 Jul;68(7):1013-8. doi: 10.1007/s00228-012-1216-7. Epub 2012 Feb 9.
Bisphosphonates are synthetic analogues of pyrophosphate usually used in treating bone disorders such as osteoporosis, Paget's disease, fibrous dysplasia, hypercalcemia of malignancy, and inflammation-related bone loss. Though therapeutic effects of bisphosphonates depend primarily on their inhibitory effect on osteoclasts, increasing attention is being given to other effector cells, such as osteoblasts. This review focuses on the presumed effect of bisphosphonates on osteoblasts.
A review of the literature was conducted to evaluate the pharmacodynamic effects of bisphosphonates including inhibition of osteoclasts and apoptosis of osteocytes and osteoblasts as well as their potential stimulatory effects on the proliferation of osteoblasts.
Studies have demonstrated that bisphosphonates may stimulate proliferation of osteoblasts and inhibit apoptosis of osteocytes and osteoblasts.
Considering that osteoblasts may be involved in bone disorders, such as osteoporosis, osteopetrosis, osteogenesis imperfecta, and Paget's disease, and that bisphosphonates may stimulate proliferation of osteoblasts and inhibit apoptosis of osteocytes and osteoblasts, it is conceivable that a role for bisphosphonates exists in these diseases beyond merely the osteoclast influence.
双膦酸盐是焦磷酸盐的合成类似物，通常用于治疗骨质疏松症、佩吉特病、纤维发育不良、恶性高钙血症和炎症相关骨丢失等骨骼疾病。虽然双膦酸盐的治疗效果主要取决于其对破骨细胞的抑制作用，但人们越来越关注其他效应细胞，如成骨细胞。本综述重点介绍双膦酸盐对成骨细胞的假定作用。
对文献进行了回顾，以评估双膦酸盐的药效学作用，包括抑制破骨细胞和破骨细胞和成骨细胞的细胞凋亡，以及它们对成骨细胞增殖的潜在刺激作用。
研究表明，双膦酸盐可能刺激成骨细胞增殖并抑制破骨细胞和成骨细胞凋亡。
鉴于成骨细胞可能参与骨质疏松症、骨质增生症、成骨不全症和佩吉特病等骨骼疾病，并且双膦酸盐可能刺激成骨细胞增殖并抑制破骨细胞和成骨细胞凋亡，因此可以想象，双膦酸盐在这些疾病中的作用不仅仅局限于对破骨细胞的影响。
