Pascual J, Liaño F, García-Villanueva A, Salvador J L, Herrero J A, Ortuño J
Department of Nephrology, Hospital Ramón y Cajal, Madrid, Spain.
J Urol. 1990 Dec;144(6):1454-6. doi: 10.1016/s0022-5347(17)39765-3.
Although breast cancer, germ cell tumors and other neoplasms are known to occur in patients with Klinefelter's syndrome, adrenal carcinoma has not yet been reported in such patients. We describe a rare case of severe primary aldosteronism as the unique manifestation of a large adrenocortical carcinoma in a patient with Klinefelter's syndrome. Complete biological and hormonal evaluation was performed. Surgical treatment was successful and the patient remained asymptomatic with normal biological and hormonal values after 1 year of followup.
虽然已知克兰费尔特综合征患者会发生乳腺癌、生殖细胞肿瘤和其他肿瘤，但此类患者中尚未有肾上腺癌的报道。我们描述了一例罕见病例，一名克兰费尔特综合征患者出现严重原发性醛固酮增多症，这是一例大型肾上腺皮质癌的唯一表现。我们进行了全面的生物学和激素评估。手术治疗成功，随访1年后患者无症状，生物学和激素值正常。
