克兰费尔特综合征与恶性淋巴瘤。

Klinefelter's syndrome and malignant lymphoma.

作者信息

Becher R

出版信息

Cancer Genet Cytogenet. 1986 Apr 1;21(3):271-3. doi: 10.1016/0165-4608(86)90008-7.

Abstract

The high risk for malignancy for carriers of several congenital chromosomal abnormalities is discussed. We report herein a patient with Klinefelter's syndrome associated with a high grade malignant non-Hodgkin lymphoma. Chromosome analysis of PHA-stimulated lymphocytes showed a mosaic of 46,XXY (90%) and normal 46,XY (10%) metaphases. To our knowledge, this is the third reported case of a malignant non-Hodgkin lymphoma in a patient with Klinefelter's syndrome in the literature.

摘要

本文讨论了几种先天性染色体异常携带者发生恶性肿瘤的高风险。我们在此报告一名患有克兰费尔特综合征并伴有高级别恶性非霍奇金淋巴瘤的患者。对PHA刺激的淋巴细胞进行染色体分析显示，中期细胞呈现46,XXY（90%）和正常46,XY（10%）的嵌合体。据我们所知，这是文献中报道的第三例克兰费尔特综合征患者发生恶性非霍奇金淋巴瘤的病例。