抑郁和健康孕妇夜间褪黑素与雌二醇和孕酮的关系。
The relationship of nocturnal melatonin to estradiol and progesterone in depressed and healthy pregnant women.
机构信息
The Center for Chronobiology, Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093-0804, USA.
出版信息
J Womens Health (Larchmt). 2012 Jun;21(6):649-55. doi: 10.1089/jwh.2011.3191. Epub 2012 Feb 9.
PURPOSE
To assess the relationship between nocturnal plasma melatonin and serum estradiol (E(2)) and progesterone (P(4)) levels in depressed pregnant women (DW) and matched healthy women (HW).
METHODS
We used analysis of variance (ANOVA) and linear regression analyses on data obtained from pregnant HW and DW.
RESULTS
Log E(2) and log P(4) were positively correlated with measures of melatonin quantity in HW (p<0.05) but not DW, controlling for age. Log E(2) and log P(4) were positively correlated with melatonin offset and duration in DW (p<0.01) but not HW.
CONCLUSIONS
Pregnant DW may be less sensitive than HW to modulation of melatonin secretion by E(2) and P(4). That melatonin timing measures are more sensitive to E(2) and P(4) variation in DW may reflect a circadian system more attuned to the need for realignment in DW than in HW. These altered sensitivities to reproductive hormones may reflect a biologic vulnerability that predisposes some pregnant women to depression.
目的
评估抑郁孕妇（DW）与匹配健康孕妇（HW）夜间血浆褪黑素与血清雌二醇（E（2））和孕酮（P（4））水平的关系。
方法
我们使用方差分析（ANOVA）和线性回归分析对来自于健康孕妇和抑郁孕妇的孕期数据进行了分析。
结果
HW 中，E（2）和 P（4）的对数与褪黑素数量的测量值呈正相关（p<0.05），但 DW 中无此相关性，且与年龄相关。DW 中，E（2）和 P（4）的对数与褪黑素的消退和持续时间呈正相关（p<0.01），但 HW 中无此相关性。
结论
与 HW 相比，DW 对 E（2）和 P（4）对褪黑素分泌的调节可能不太敏感。DW 中褪黑素时间测量对 E（2）和 P（4）变化更为敏感，可能反映出 DW 的昼夜节律系统比 HW 更需要重新调整。对生殖激素的这些改变的敏感性可能反映了一种生物学脆弱性，使一些孕妇容易患上抑郁症。
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