Uchizono A, Ohyama M, Nishi J, Yoshinaga M, Miyata K, Miyanohara H, Deguchi K
Department of Otolaryngology, School of Medicine, Kagoshima University.
Rinsho Byori. 1990 Sep;38(9):998-1004.
A retrospective study of the characteristics of MRSA (methicillin resistant S. aureus) in Kagoshima University Hospital and its ENT department was reported. There were 231 samples (104 strains) MRSA in all S. aureus 448 samples from Jan. to Sep. 1989 in Kagoshima University Hospital, in which 58 strains (55.8%) were coagulase type II and 35 strains (33.7%) were type VII. The much more predominant numbers of MRSA were observed in all the cases inpatients clinics in surgery, pediatrics, urology, gynecology and dermatology than internal medicine as well as outpatients clinics. In ENT department of this hospital, only 15.4% of all S. aureus were MRSA. On the other hand, bacteriological survey showed 26% of MRSA out of all S. aureus which were detected at Tokyo clinical research center on otorrhea in the patients with chronic otitis media as multicenter clinical trial of Japan. Two cases involved by MRSA after postoperative administration of many types of antibiotics were also demonstrated. These MRSAs were producing type II coagulase and very high concentrations of MICs to many antibiotics were observed. But these cases were not severe and MINO (minocyclin) or GM (gentamicin) were so effective. The effect of combined therapy of some antibiotics or antimicrobial agents was discussed briefly.
一项关于鹿儿岛大学医院及其耳鼻喉科耐甲氧西林金黄色葡萄球菌（MRSA）特征的回顾性研究被报道。1989年1月至9月期间，鹿儿岛大学医院从448份金黄色葡萄球菌样本中分离出231份样本（104株）MRSA，其中58株（55.8%）为凝固酶II型，35株（33.7%）为VII型。与内科以及门诊相比，在外科、儿科、泌尿外科、妇科和皮肤科的所有住院患者病例中观察到的MRSA数量要多得多。在该医院的耳鼻喉科，所有金黄色葡萄球菌中只有15.4%是MRSA。另一方面，细菌学调查显示，在作为日本多中心临床试验的慢性中耳炎患者耳漏东京临床研究中心检测到的所有金黄色葡萄球菌中，MRSA占26%。还展示了两例在术后使用多种抗生素后感染MRSA的病例。这些MRSA产生II型凝固酶，并且观察到对多种抗生素的最低抑菌浓度（MIC）非常高。但这些病例并不严重，米诺环素（美满霉素）或庆大霉素非常有效。还简要讨论了一些抗生素或抗菌剂联合治疗的效果。
