与吸烟相关的肺泡巨噬细胞中的肺药物代谢酶

Pulmonary drug-metabolizing enzyme in alveolar macrophages in relation to cigarette smoking.

作者信息

Abe S, Makimura S, Ogura S, Nakajima I, Kawakami Y

机构信息

First Department of Medicine, School of Medicine, Hokkaido University, Sapporo, Japan.

出版信息

Jpn J Med. 1990 Mar-Apr;29(2):164-7. doi: 10.2169/internalmedicine1962.29.164.

DOI:10.2169/internalmedicine1962.29.164

PMID:2232364

Abstract

We measured the aryl hydrocarbon hydroxylase (AHH) activity in alveolar macrophages (AMs) and the AHH inducibility in peripheral blood lymphocytes (PBLs) of 56 subjects with and without lung cancer. There were no differences in the AHH inducibility in PBLs whether or not the host had lung cancer, regardless of a smoking history. The AHH activity in AMs in the current smoker group was significantly higher than in the non-smoker group. The AHH activity in AMs in the lung cancer group was higher than that in the non-lung cancer group, and the central-type group was significantly higher than the peripheral-type group. These results suggest that the AHH activity in AMs is associated with the development of lung cancer and a history of cigarette smoking.

摘要

我们检测了56例有或无肺癌患者肺泡巨噬细胞（AMs）中的芳烃羟化酶（AHH）活性以及外周血淋巴细胞（PBLs）中的AHH诱导性。无论宿主是否患有肺癌，无论有无吸烟史，PBLs中的AHH诱导性均无差异。当前吸烟者组AMs中的AHH活性显著高于非吸烟者组。肺癌组AMs中的AHH活性高于非肺癌组，中央型组显著高于外周型组。这些结果表明，AMs中的AHH活性与肺癌的发生及吸烟史有关。