Mclemore T L, Martin R R
Cancer Lett. 1977 May;2(6):327-33. doi: 10.1016/s0304-3835(77)80013-x.
Aryl hydrocarbon hydroxylase (AHH) was induced in human pulmonary alveolar macrophages (PAMs) cultured in the presence of benzanthracene. Time and dose--response curves were established for in vitro induction of this enzyme system in PAMs. In addition, a positive correlation was noted between the level of AHH activity in freshly lavaged PAMs and the in vitro inducibility of the enyzme in these cells from either nonsmokers or cigarette smokers. Measurements of the inducibility of AHH in cultured human PAMs provide an experimental system suitable for studying the mechanisms responsible for the initiation of pulmonary carcinogenesis.
在苯并蒽存在的情况下培养的人肺泡巨噬细胞（PAM）中，芳烃羟化酶（AHH）被诱导。建立了PAM中该酶系统体外诱导的时间和剂量反应曲线。此外，在新鲜灌洗的PAM中AHH活性水平与这些细胞（无论是非吸烟者还是吸烟者）中该酶的体外诱导性之间发现了正相关。在培养的人PAM中测量AHH的诱导性提供了一个适合研究肺致癌作用起始机制的实验系统。
