Kurashima K, Kawamura Y, Ohka T, Hayashi M, Matsuda T
Ishikawa Prefectural Central Hospital, Kanazawa, Japan.
Jpn J Med. 1990 Mar-Apr;29(2):226-9. doi: 10.2169/internalmedicine1962.29.226.
Primary myelofibrosis terminating in megakaryoblastic crisis is uncommon. A case with this condition is reported. The patient, a 62-year-old female, having had primary myelofibrosis for 13 years and a splenectomy 4 years before, was admitted because of high fever, hepatomegaly, thrombocythemia and leukocytosis. On admission, blasts appeared in the peripheral blood and thereafter gradually increased in number. The blasts were proven to be of megakaryocytic lineage. To our knowledge this is the third case of primary myelofibrosis terminating in megakaryoblastic crisis to be reported in Japan.
以巨核母细胞危象为终末期表现的原发性骨髓纤维化并不常见。本文报告了1例这种情况的病例。该患者为62岁女性，患原发性骨髓纤维化13年，4年前行脾切除术，因高热、肝肿大、血小板增多症和白细胞增多症入院。入院时外周血中出现原始细胞，此后数量逐渐增加。这些原始细胞被证实为巨核细胞系。据我们所知，这是日本报告的第三例以巨核母细胞危象为终末期表现的原发性骨髓纤维化病例。
