Department of Surgery, National Police Hospital, Seoul, Korea.
J Gastric Cancer. 2011 Dec;11(4):195-9. doi: 10.5230/jgc.2011.11.4.195. Epub 2011 Dec 29.
Composite neuroendocrine-exocrine carcinomas are malignancies that have two distinct components residing within the same tumor: an adenocarcinomatous portion and a neuroendocrine portion. This is rare in gastric cancers; however, poorly differentiated adenocarcinomas can sometimes reveal evidence of neuroendocrine features (NEF) or be 'mixed endocrine and exocrine carcinomas'. This study aimed to review NEF in gastric adenocarcinoma and to evaluate its prognostic significance.
We selected 29 patients who were diagnosed with gastric adenocarcinoma with NEF and received gastrectomies at the Department of Surgery, Ajou University Hospital between January 2001 and December 2009. We analyzed the clinicopathologic features of gastric cancer with NEF and the prognosis associated with such tumors.
THE PATHOLOGIC RESULT WITH RESPECT TO TNM STAGING OF THE GASTRIC CANCERS WITH NEF WERE AS FOLLOWS: 5 cases of T1, 5 cases of T2, 10 cases of T3, and 9 cases of T4. There were 7 cases of N0, 7 cases of N1, 8 cases of N2 and 7 cases of N3. The staging of patients with NEF was higher than that of patients without NEF. Especially tumor lymphovascular invasion rate was 82.8%. The overall survival of patients with gastric cancer characterized by NEF was 73.8 months.
Positive NEF status might be correlated with clinicopathologic parameters such as a high stage and high frequency of regional lymph node metastasis.
复合神经内分泌-外分泌癌是一种恶性肿瘤，其同一肿瘤内存在两种不同成分：腺癌部分和神经内分泌部分。这种情况在胃癌中很少见；然而，低分化腺癌有时可能会出现神经内分泌特征（NEF）的证据，或者是“混合内分泌和外分泌癌”。本研究旨在回顾胃腺癌中的 NEF，并评估其预后意义。
我们选择了 29 名在 2001 年 1 月至 2009 年 12 月期间在 Ajou 大学医院外科接受胃切除术的诊断为胃腺癌伴 NEF 的患者。我们分析了伴有 NEF 的胃癌的临床病理特征及其与肿瘤相关的预后。
伴有 NEF 的胃癌的病理结果与 TNM 分期如下：T1 期 5 例，T2 期 5 例，T3 期 10 例，T4 期 9 例。N0 期 7 例，N1 期 7 例，N2 期 8 例，N3 期 7 例。伴有 NEF 的患者分期高于无 NEF 的患者。特别是肿瘤淋巴管血管侵犯率为 82.8%。伴有 NEF 的胃癌患者的总体生存率为 73.8 个月。
阳性 NEF 状态可能与临床病理参数相关，如高分期和区域淋巴结转移的高频率。
