Prevention of Metabolic Disorders Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Metab Syndr Relat Disord. 2012 Jun;10(3):218-24. doi: 10.1089/met.2011.0070. Epub 2012 Feb 10.
Obesity is one of the most important cardiovascular disease (CVD) risk factors among diabetic populations. We evaluated the ability of different anthropometric measures for predicting CVD among type 2 diabetic patients.
The study consisted of 411 men and 599 women, aged ≥30 years, free of CVD at baseline with a median follow-up of 8.4 years. The adjusted hazard ratios (HRs) for CVD were calculated for a 1 standard deviation change in body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), and waist-to-height ratio (WHtR) using Cox proportional regression analysis.
A total of 188 CVD events occurred (men, 90; women, 98). In women, in confounder-adjusted analysis [age, fasting plasma glucose (instead of glycosylated hemoglobin), and positive family history of CVD], WHR was associated with incident CVD [1.32 (1.06-1.65)], followed by WC and WHtR, which were marginally significant (P=0.06 and 0.08, respectively); after adjustment for hypertension and hypercholesterolemia, only WHR predicted CVD significantly. In men, the confounder-adjusted (age, fasting plasma glucose, and aspirin use) HR to predict CVD was significant only for WHR [HR 1.21(1.00-1.48)].
This study showed WHR was the most powerful predictor of CVD among anthropometric measures, followed by WHtR, in diabetic population.
肥胖是糖尿病患者中心血管疾病（CVD）最重要的危险因素之一。我们评估了不同人体测量指标预测 2 型糖尿病患者 CVD 的能力。
该研究纳入了 411 名男性和 599 名年龄≥30 岁的无 CVD 基线患者，中位随访时间为 8.4 年。使用 Cox 比例风险回归分析，计算了体重指数（BMI）、腰围（WC）、腰臀比（WHR）和腰围身高比（WHtR）每增加 1 个标准差的 CVD 调整后危险比（HR）。
共发生 188 例 CVD 事件（男性 90 例，女性 98 例）。在女性中，在调整混杂因素（年龄、空腹血糖（而非糖化血红蛋白）和 CVD 阳性家族史）后，WHR 与 CVD 事件相关（1.32[1.06-1.65]），其次是 WC 和 WHtR，差异有统计学意义（P=0.06 和 0.08）；在调整高血压和高脂血症后，只有 WHR 显著预测 CVD。在男性中，经混杂因素调整（年龄、空腹血糖和阿司匹林使用）后，预测 CVD 的 HR 仅对 WHR 有意义[HR 1.21（1.00-1.48）]。
本研究表明，在糖尿病人群中，WHR 是预测 CVD 的最强人体测量指标，其次是 WHtR。
