Neufeld A H
Surv Ophthalmol. 1979 May-Jun;23(6):363-70. doi: 10.1016/0039-6257(79)90229-7.
Timolol, which binds to beta-adrenergic receptors, is a potent antagonist of the catecholamine-stimulated synthesis of cyclic AMP. However, the actual mechanism of action by which timolol reduces intraocular pressure is not readily apparent. Compared to its efficacy in human eyes, the drug is relatively ineffective in rabbit eyes. A reasonable postulate is that soon after administration, timolol blocks endogenous adrenergic stimulation contributing to the formation of aqueous humor by the ciliary processes. Nevertheless, the long-lasting reduction of intraocular pressure persists at a time when the drug is no longer bound to beta-adrenergic receptors.
噻吗洛尔可与β-肾上腺素能受体结合，是儿茶酚胺刺激的环磷酸腺苷合成的强效拮抗剂。然而，噻吗洛尔降低眼压的实际作用机制尚不清楚。与在人眼中的疗效相比，该药物在兔眼中相对无效。一个合理的推测是，给药后不久，噻吗洛尔会阻断内源性肾上腺素能刺激，而这种刺激有助于睫状体产生房水。然而，当药物不再与β-肾上腺素能受体结合时，眼压仍会持续长时间降低。
