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Laboratory and clinical studies on the mechanism of action of timolol.

作者信息

Neufeld A H, Bartels S P, Liu J H

出版信息

Surv Ophthalmol. 1983 Dec;28 Suppl:286-92. doi: 10.1016/0039-6257(83)90152-2.

DOI:10.1016/0039-6257(83)90152-2
PMID:6320482
Abstract

Timolol is now widely used in the treatment of glaucoma but its mechanism of action is unclear. The drug decreases aqueous humor formation by the ciliary processes and is a potent beta-adrenergic antagonist. However, the physiological basis for such a drug to decrease intraocular pressure has not been clearly demonstrated.

摘要

相似文献

1
Laboratory and clinical studies on the mechanism of action of timolol.
Surv Ophthalmol. 1983 Dec;28 Suppl:286-92. doi: 10.1016/0039-6257(83)90152-2.
2
Experimental studies on the mechanism of action of timolol.噻吗洛尔作用机制的实验研究
Surv Ophthalmol. 1979 May-Jun;23(6):363-70. doi: 10.1016/0039-6257(79)90229-7.
3
Effects of timolol, terbutaline and forskolin on IOP, aqueous humour formation and ciliary cyclic AMP levels in the bovine eye.噻吗洛尔、特布他林和福斯高林对牛眼眼压、房水生成及睫状体环磷酸腺苷水平的影响。
Curr Eye Res. 1995 Jul;14(7):519-28. doi: 10.3109/02713689508998398.
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Ocular hypotension in the rabbit. Receptor mechanisms of pirbuterol and nylidrin.
Invest Ophthalmol Vis Sci. 1985 Feb;26(2):163-9.
5
R-enantiomer of timolol: a potential selective ocular antihypertensive agent.噻吗洛尔的R-对映体:一种潜在的选择性眼部抗高血压药物。
Graefes Arch Clin Exp Ophthalmol. 1984;221(5):234-8. doi: 10.1007/BF02134145.
6
In vivo cAMP level in rabbit iris-ciliary body after topical epinephrine treatment.
Curr Eye Res. 1996 Oct;15(10):1025-32. doi: 10.3109/02713689609017651.
7
Timolol may inhibit aqueous humor secretion by cAMP-independent action on ciliary epithelial cells.噻吗洛尔可能通过对睫状上皮细胞的非环磷酸腺苷(cAMP)依赖性作用来抑制房水分泌。
Am J Physiol Cell Physiol. 2001 Sep;281(3):C865-75. doi: 10.1152/ajpcell.2001.281.3.C865.
8
ICI 118,551: an effective ocular hypotensive agent with selectivity for the ciliary process beta 2-adrenoceptor and with minimal cardiac side effects.ICI 118,551:一种有效的降眼压药物,对睫状突β2肾上腺素能受体具有选择性,且心脏副作用极小。
Br J Pharmacol. 1984 Nov;83(3):821-9. doi: 10.1111/j.1476-5381.1984.tb16238.x.
9
Regulation and bioelectrical effects of cyclic adenosine monophosphate production in the ciliary epithelial bilayer.睫状上皮双层中环状单磷酸腺苷生成的调节及生物电效应
Invest Ophthalmol Vis Sci. 1996 Mar;37(4):607-12.
10
Pharmacological effects of topical timolol in the rabbit eye.噻吗洛尔滴眼液对兔眼的药理作用。
Invest Ophthalmol Vis Sci. 1980 Oct;19(10):1189-97.

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Elevation of intraocular pressure in glaucoma patients after automated visual field testing.
青光眼患者行自动视野检查后眼压升高。
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Rational use of the fixed combination of dorzolamide - timolol in the management of raised intraocular pressure and glaucoma.多佐胺-噻吗洛尔固定复方制剂在高眼压症和青光眼治疗中的合理应用。
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Is topical haloperidol a useful glaucoma treatment?局部用氟哌啶醇是一种有效的青光眼治疗方法吗?
Br J Ophthalmol. 1986 Jun;70(6):448-50. doi: 10.1136/bjo.70.6.448.
6
The role of apraclonidine hydrochloride in laser therapy for glaucoma.盐酸阿可乐定在青光眼激光治疗中的作用。
Trans Am Ophthalmol Soc. 1989;87:729-61.
7
New developments in the drug treatment of glaucoma.青光眼药物治疗的新进展。
Drugs. 1991 Apr;41(4):514-32. doi: 10.2165/00003495-199141040-00002.