Ober M, Scharrer A
Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1980;213(4):273-81. doi: 10.1007/BF00417550.
Twenty-seven patients with ocular hypertension or open angle glaucoma were tested to see if, and to what extent, timolol and dipivalyl-epinephrine produced a supplementary reduction of intraocular pressure. In a shortterm study, 14 patients were tested with timolol (0.1%) and dipivalyl-epinephrine (0.25%). Simultaneous application of both substances produced a statistically more significant reduction of intraocular pressure than either timolol (0.1%) or dipivalyl-epinephrine (0.25%) alone. In 13 patients a comparison was made between patients who received both timolol (0.25%) and dipivalyl-epinephrine (0.1%) bis x and patients who received only timolol (0.25%) bis x over a period of 6, 9 and 12 weeks. Both substances used in combination produced a statistically more significant reduction in intraocular pressure than timolol (0.25%) bis x alone. The simultaneous application of an alpha and beta-adrenergic agonist and beta-adrenergic antagonist is not contradictory. The results are discussed on the basis of the mode of action of the applied substances.
对27例高眼压症或开角型青光眼患者进行测试，以观察噻吗洛尔和二特戊酰肾上腺素是否以及在何种程度上能产生额外的眼压降低效果。在一项短期研究中，对14例患者使用噻吗洛尔（0.1%）和二特戊酰肾上腺素（0.25%）进行测试。两种药物同时应用时，眼压降低程度在统计学上比单独使用噻吗洛尔（0.1%）或二特戊酰肾上腺素（0.25%）更显著。对13例患者进行了为期6周、9周和12周的比较，一组患者接受噻吗洛尔（0.25%）和二特戊酰肾上腺素（0.1%）各两次，另一组患者仅接受噻吗洛尔（0.25%）各两次。两种药物联合使用时，眼压降低程度在统计学上比单独使用噻吗洛尔（0.25%）各两次更显著。同时应用α和β肾上腺素能激动剂以及β肾上腺素能拮抗剂并不矛盾。根据所用药物的作用方式对结果进行了讨论。
