Santos T, Drummond M, Botelho F
Faculdade de Medicina, Universidade do Porto, Porto, Portugal.
Rev Port Pneumol. 2012 Mar-Apr;18(2):64-71. doi: 10.1016/j.rppneu.2011.10.004. Epub 2012 Feb 9.
OSAS (Obstructive Sleep apnea syndrome) is defined by recurrent episodes of upper airway obstruction during sleep, causing multiple clinical consequences. Literature review suggests that OSAS induces a spectrum of abnormalities in neural, hormonal and vascular regulation that contribute to the development of ED (erectile dysfunction). The aims of this study were to estimate the prevalence of ED in OSAS patients and evaluate its determinants.
62 patients from Hospital S. João Sleep Laboratory with newly diagnosed OSAS were included in the study and answered the IIEF-5 (international index erectile function 5 item version) questionnaire.
The prevalence of ED in OSAS patients was 64.4%. Age and Diabetes constituted themselves as independent risk factors for more severe degrees of ED: OR=1.226 (95%CI: 1.062-1.415) and OR=31.205 (95%CI: 1.222-796.557), respectively. Compared with nonsmokers, ex-smokers group revealed a positive association with ED: OR=4.32 (95%CI: 1.09-17.11). Hypertension and ACEI (angiotensin converting enzyme inhibitors) or ARB (angiotensin II receptor blockers) therapy were also correlated to ED symptoms: OR=3.25 (95%CI: 1.09-9.65) and 7.39 (95%CI: 1.52-35.99), respectively. No association was found relating BMI (p=0.254), alcoholic habits (p=0.357), acute myocardial infarction (p=0.315), dyslipidemia (p=0.239),metabolic syndrome (p=0.215) and ED. OSAS severity was not associated with ED in our sample.
The prevalence of ED in OSAS patients is high. ED determinants in our sample were age and diabetes. Past smoking habits, hypertension and ACEI/ARB therapy also revealed a statistically significant association with ED.
阻塞性睡眠呼吸暂停综合征（OSAS）的定义是睡眠期间上呼吸道反复阻塞，会引发多种临床后果。文献综述表明，OSAS会在神经、激素和血管调节方面引发一系列异常，这些异常会导致勃起功能障碍（ED）的发生。本研究的目的是评估OSAS患者中ED的患病率，并评估其决定因素。
来自圣若昂医院睡眠实验室的62例新诊断为OSAS的患者被纳入研究，并回答了国际勃起功能指数5项版（IIEF-5）问卷。
OSAS患者中ED的患病率为64.4%。年龄和糖尿病是更严重程度ED的独立危险因素：比值比（OR）分别为1.226（95%置信区间：1.062 - 1.415）和31.205（95%置信区间：1.222 - 796.557）。与不吸烟者相比，已戒烟者组与ED呈正相关：OR = 4.32（95%置信区间：1.09 - 17.11）。高血压以及血管紧张素转换酶抑制剂（ACEI）或血管紧张素II受体阻滞剂（ARB）治疗也与ED症状相关：OR分别为3.25（95%置信区间：1.09 - 9.65）和7.39（95%置信区间：1.52 - 35.99）。未发现体重指数（BMI）（p = 0.254）、饮酒习惯（p = 0.357）、急性心肌梗死（p = 0.315）、血脂异常（p = 0.239）、代谢综合征（p = 0.215）与ED之间存在关联。在我们的样本中，OSAS严重程度与ED无关。
OSAS患者中ED的患病率很高。我们样本中ED的决定因素是年龄和糖尿病。既往吸烟习惯、高血压以及ACEI/ARB治疗也显示与ED存在统计学上的显著关联。
