Supiot S, Paris F
Inserm UMR892, centre de recherche en cancérologie Nantes-Angers, 8, quai Moncousu, 44007 Nantes cedex 01, France.
Cancer Radiother. 2012 Feb;16(1):11-5. doi: 10.1016/j.canrad.2011.10.006. Epub 2012 Feb 10.
Radiotherapy is used in more than 60% of the curative or palliative intent treatment against cancer. However, its effectiveness is often limited by intrinsic resistance of cancer cells and the radiation toxicity of the surrounding normal tissue. New paradigms in oncology are not only focused on tumor cells, but also considered non-transformed from the stromal cells as potential therapeutic target. Among the different cell types, endothelial cells play a singular role, due by their presence, in the vast majority of tumors but also of healthy tissue. This review proposes to participate in the understanding of the response of the endothelium, in the radiation sensitivity of tumor and healthy tissue after radiotherapy.
放射疗法用于超过60%的针对癌症的根治性或姑息性治疗。然而，其有效性常常受到癌细胞的内在抗性以及周围正常组织的放射毒性的限制。肿瘤学的新范式不仅关注肿瘤细胞，还将未转化的基质细胞视为潜在的治疗靶点。在不同的细胞类型中，内皮细胞发挥着独特的作用，这是由于它们在绝大多数肿瘤以及健康组织中均有存在。本综述旨在促进对内皮细胞反应、放疗后肿瘤和健康组织的放射敏感性的理解。
