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某些 O-半乳糖脂衍生物的端基异构体混合物比单一端基异构体对癌细胞的毒性更大。

The anomeric mixture of some O-galactolipid derivatives is more toxic against cancer cells than either anomer alone.

机构信息

Key Laboratory for Advanced Materials & Institute of Fine Chemicals, East China University of Science and Technology, Shanghai 200237, PR China.

出版信息

Bioorg Med Chem Lett. 2012 Mar 1;22(5):2030-2. doi: 10.1016/j.bmcl.2012.01.069. Epub 2012 Jan 28.

Abstract

The anomeric mixture of a series of O-galactolipid derivatives is revealed to be more toxic against several cancer cell lines than their either single component with the pure α- or β-configuration. This interesting phenomenon has been confirmed on pairs of synthesized O-galactosyl anomers bearing length-varied alkyl chains at the lipid end. Furthermore, the most potent mixture was determined inoffensive to a normal cell line tested.

摘要

一系列 O-半乳糖脂衍生物的端基非对映混合物被证明比其单一成分(纯 α-或 β-构型)对多种癌细胞系更具毒性。这种有趣的现象已经在带有不同长度烷基链的合成 O-半乳糖基端基非对映体对中得到证实。此外,在所测试的正常细胞系中,最有效的混合物被确定为无毒性。

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