Key Laboratory for Advanced Materials & Institute of Fine Chemicals, East China University of Science and Technology, Shanghai 200237, PR China.
Bioorg Med Chem Lett. 2012 Mar 1;22(5):2030-2. doi: 10.1016/j.bmcl.2012.01.069. Epub 2012 Jan 28.
The anomeric mixture of a series of O-galactolipid derivatives is revealed to be more toxic against several cancer cell lines than their either single component with the pure α- or β-configuration. This interesting phenomenon has been confirmed on pairs of synthesized O-galactosyl anomers bearing length-varied alkyl chains at the lipid end. Furthermore, the most potent mixture was determined inoffensive to a normal cell line tested.
一系列 O-半乳糖脂衍生物的端基非对映混合物被证明比其单一成分（纯 α-或 β-构型）对多种癌细胞系更具毒性。这种有趣的现象已经在带有不同长度烷基链的合成 O-半乳糖基端基非对映体对中得到证实。此外，在所测试的正常细胞系中，最有效的混合物被确定为无毒性。
