Lv Ming-ming, Fan Xin-dong, Su Li-xin
Department of Oral & Maxillofacial Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, PR China.
Int J Pediatr Otorhinolaryngol. 2012 Apr;76(4):574-8. doi: 10.1016/j.ijporl.2012.01.020. Epub 2012 Feb 11.
Infantile hemangiomas (IHs) on head and neck are frequently encountered. Recently, propranolol was introduced as a novel pharmacologic treatment for IH. But the impact of propranolol for the treatment of IHs especially the side effects have not yet been well described. This article aimed to describe the effects and side effects of propranolol treatment in 37 children with problematic hemangiomas on head and neck.
Data were collected from the medical charts of patients treated between October 2008 and November 2010. Serial examinations and photographs were obtained to evaluate perceived therapeutic response and complications of oral propranolol in the course of their therapy.
Thirty-seven infants with propranolol-treated problematic head and neck hemangiomas were included and all patients had a good response. Most of patients were subjectively noticed an obvious improvement within one week from the onset of therapy. 29 patients endured the treatment of propranolol for 3 months with no recurrence, 6 patients endured prolonged course of treatment for 5/6 months. 2 patients who endured the treatment of propranolol for 3 months were found recurrence in two weeks. So the propranolol was given again for another 3 months. There were no severe adverse reactions. Minor side effects included diarrhea, light sleeping, and nausea.
Propranolol appears to be an effective and well-tolerated treatment for problematic IH on head and neck.
头颈部婴幼儿血管瘤（IHs）较为常见。近来，普萘洛尔被引入作为治疗IH的一种新型药物疗法。但普萘洛尔治疗IH的效果尤其是副作用尚未得到充分描述。本文旨在描述普萘洛尔治疗37名头颈部有问题血管瘤患儿的疗效及副作用。
收集2008年10月至2010年11月期间接受治疗患者的病历资料。在治疗过程中进行系列检查并拍照，以评估口服普萘洛尔的治疗反应及并发症。
纳入37例接受普萘洛尔治疗的头颈部有问题血管瘤患儿，所有患者反应良好。大多数患者在治疗开始后一周内主观上明显改善。29例患者接受普萘洛尔治疗3个月无复发，6例患者接受延长疗程5/6个月。2例接受普萘洛尔治疗3个月的患者在两周后复发，因此再次给予普萘洛尔治疗3个月。无严重不良反应。轻微副作用包括腹泻、睡眠浅和恶心。
普萘洛尔似乎是治疗头颈部有问题IH的一种有效且耐受性良好的疗法。
