Department of Dermatology, Hôtel-Dieu, 44093 Nantes, France.
J Am Acad Dermatol. 2011 May;64(5):827-32. doi: 10.1016/j.jaad.2010.12.040. Epub 2011 Feb 25.
Ulcerated infantile hemangiomas (IH) are a therapeutic challenge. Propranolol, a nonselective beta-blocker, was recently introduced as a novel treatment for IH.
To evaluate our experience of propranolol in the management of ulcerated IH.
A national, multicenter, retrospective, observational study was conducted. Data were collected from the medical charts of patients treated from 2008 to 2009 and supplemented by information obtained from parents during targeted telephone interviews.
Thirty-three infants with propranolol-treated ulcerated IH were included. The average time to complete ulceration healing was 4.3 weeks in 30 of 33 patients and was significantly faster for head-and-neck locations (P = .0354). The mean time to complete pain control was 14.5 days. Parents rated treatment as very effective for 27 of 31 patients and very well tolerated for 29 of 31 cases.
This was a retrospective uncontrolled study.
Propranolol appears to be an effective and well-tolerated treatment for ulcerated IH.
溃疡性婴幼儿血管瘤（IH）是一种治疗上的挑战。普萘洛尔，一种非选择性β受体阻滞剂，最近被引入作为 IH 的一种新的治疗方法。
评估我们在溃疡性 IH 管理中使用普萘洛尔的经验。
进行了一项全国性、多中心、回顾性、观察性研究。数据从 2008 年至 2009 年接受治疗的患者的病历中收集，并通过有针对性的电话访谈从家长处获得的信息进行补充。
33 例接受普萘洛尔治疗的溃疡性 IH 婴儿被纳入研究。33 例患者中的 30 例在 4.3 周内完成溃疡愈合，头颈部位置的愈合时间明显更快（P =.0354）。完全缓解疼痛的平均时间为 14.5 天。27 例患者中的 27 例家长认为治疗非常有效，29 例患者中的 29 例认为治疗耐受性非常好。
这是一项回顾性非对照研究。
普萘洛尔似乎是一种有效且耐受性良好的溃疡性 IH 治疗方法。
Zotero 插件