Thieme S, Walther M, Pietzsch H-J, Henniger J, Preusche S, Mäding P, Steinbach J
Institute of Radiopharmacy, Helmholtz-Zentrum Dresden-Rossendorf, P.O. Box 510 119, 01314 Dresden, Germany.
Appl Radiat Isot. 2012 Apr;70(4):602-8. doi: 10.1016/j.apradiso.2012.01.019. Epub 2012 Feb 1.
In this work the production of (64)Cu via the (64)Ni(p,n)(64)Cu reaction with optimized conditions for low current irradiation is presented. Different target setups and cleaning steps for lowering metal contaminations in the product were applied. (64)Cu with high specific activities up to 1685 GBq/μmol was produced despite low overall activity (≈ 4.2 GBq per run). The module processing leads to a highly reproducible, reliable product quality (<1 μg Cu and <7 μg Ni). Besides its diagnostic value (64)Cu may be of interest even for therapeutic purposes due to its decay characteristics.
在这项工作中，介绍了通过(64)Ni(p,n)(64)Cu反应在低电流辐照的优化条件下生产(64)Cu的情况。采用了不同的靶材设置和清洗步骤以降低产品中的金属污染。尽管总体活度较低（每次运行约4.2 GBq），但仍生产出了比活度高达1685 GBq/μmol的(64)Cu。模块加工导致了高度可重复、可靠的产品质量（<1 μg Cu和<7 μg Ni）。除了其诊断价值外，由于(64)Cu的衰变特性，它甚至可能在治疗目的方面也具有应用价值。
