Guijarro de Armas M A Guadalupe, Monereo Megías Susana, Merino Viveros María, Iglesias Bolaños Paloma, Vega Piñero Belén
Servicio Endocrinología y Nutrición, Hospital Universitario de Getafe, Madrid, España.
Endocrinol Nutr. 2012 Mar;59(3):155-9. doi: 10.1016/j.endonu.2012.01.003. Epub 2012 Feb 10.
Childhood obesity is a major and increasing health problem for society because it increases the risk of cardiovascular disease, type 2 diabetes mellitus, and hypertension. Thus, when obese children become obese adults, effects on their health and life expectation may be devastating.
A descriptive, cross-sectional study was conducted in children and adolescents with severe obesity (weight>p97) seen at the endocrinology department of Hospital de Getafe. Variables examined included age, sex, height, weight, body mass index (BMI),waist circumference(WC), oral glucose tolerance test (OGTT), insulin, insulin resistance (IR) measured by HOMA, triglycerides (TG), HDL, and systolic and diastolic blood pressure (SBP and DBP). The definition of MS in adolescents was made according to criteria of the International Diabetes Federation (IDF), 2007.
A total of 133 patients, 67 males (50.4%) and 66 females (49.6%) with a mean age of 12.17 ± 3.27 years, were enrolled into the study. All patients were obese, with a weight greater than the 97 h percentile for age and sex. Prevalence of several cardiovascular risk factors was as follows: WC ≥ 90th percentile for age and sex, 100%; hypertension, 26.08%; hypertriglyceridemia ≥ 150 mg/dL, 15.94%; HDL <40 mg/dL, 10.86%; fasting blood glucose levels ≥ 100mg/dL, 7.97%. The overall prevalence of metabolic syndrome was 19.6%. A comparison of different anthropometric and biochemical parameters in patients with 1 or 2 MS criteria to those with 3 or more criteria showed that obesity and insulin resistance were significantly greater the greater the number of MS criteria met.
1.) Prevalence of MS in obese children and adolescents is high, 2). Arterial hypertension and hypertriglyceridemia are the most prevalent metabolic changes in the population studied and 3). Early intervention to control childhood obesity is essential to prevent cardiovascular morbidity and mortality in the future.
儿童肥胖是一个对社会来说日益严重的主要健康问题，因为它会增加患心血管疾病、2型糖尿病和高血压的风险。因此，当肥胖儿童成长为肥胖成年人时，对他们健康和预期寿命的影响可能是毁灭性的。
1）评估肥胖儿童人群中代谢综合征（MS）的患病率。2）比较符合一项或两项MS综合征参数的患者与符合MS标准的患者的人体测量和生化参数。
在赫塔费医院内分泌科对严重肥胖（体重>第97百分位）的儿童和青少年进行了一项描述性横断面研究。检查的变量包括年龄、性别、身高、体重、体重指数（BMI）、腰围（WC）、口服葡萄糖耐量试验（OGTT）、胰岛素、通过稳态模型评估（HOMA）测量的胰岛素抵抗（IR）、甘油三酯（TG）、高密度脂蛋白（HDL）以及收缩压和舒张压（SBP和DBP）。青少年MS的定义依据国际糖尿病联盟（IDF）2007年的标准。
共有133名患者纳入研究，其中67名男性（50.4%），66名女性（49.6%），平均年龄为12.17±3.27岁。所有患者均肥胖，体重超过年龄和性别的第97百分位。几种心血管危险因素的患病率如下：WC≥年龄和性别的第90百分位，100%；高血压，26.08%；高甘油三酯血症≥150mg/dL，15.94%；HDL<40mg/dL，10.86%；空腹血糖水平≥100mg/dL，7.97%。代谢综合征的总体患病率为19.6%。对符合1或2项MS标准的患者与符合3项或更多标准的患者的不同人体测量和生化参数进行比较，结果显示符合的MS标准数量越多，肥胖和胰岛素抵抗就越显著。
1）肥胖儿童和青少年中MS的患病率很高。2）动脉高血压和高甘油三酯血症是所研究人群中最常见的代谢变化。3）早期干预以控制儿童肥胖对于预防未来心血管疾病的发病和死亡至关重要。
