Figueroa Sobrero Angela, Evangelista Patricia, Kovalskys Irina, Digón Patricia, López Stella, Scaiola Edit, Perez Norma, Dieuzeide Guillermo, Walz Florencia, Mazza Carmen
Hospital San Roque, Servicio de Endocrinología, Diabetes y Nutrición, Paraná, Entre Ríos, Argentine.
Sociedad Argentina de Diabetes, Buenos Aires, Argentine.
Diabetes Metab Syndr. 2016 Jan-Mar;10(1 Suppl 1):S103-9. doi: 10.1016/j.dsx.2015.10.003. Epub 2015 Oct 24.
Obesity and its complications are emerging in an epidemic manner in Latin American countries.
To estimate the prevalence of Cardio-Metabolic Risk Factors (CMRFs) and Metabolic Syndrome (MS) in overweight/obese (OW/OB) and normal weight (NW) adolescents and to examine the associated variables.
A cross-sectional comparative study was conducted in two groups of children, between 10 and 19 years of age, in seven Argentine provinces. A survey on dietary habits, physical activity, anthropometric and biochemical data was collected to identify CMRF and MS. The WHO definition adapted to children was used.
1009 children were assessed; 398 were male (39.4%), 601 (59.6%) were NW and 408 (40.4%) were OW/OB. The OW/OB had a significantly higher proportion of values defined as CMRF: 3.7% impaired fasting glucose >110mg/dl; 27.9% insulin >15 or 20μU/l as they were pubertal/prepubertal; 53.2% Homeostatic Model Assessment (HOMA)>2.5; 45.6% High Density Lipoprotein (HDL)<40mg/dl; 37.7% TG>110mg/dl and 13.5% hypertension (SBP and/or diastolic Blood Pressure percentile >90). Prevalence of the MS in OW/OB patients was 40.3%. The MS was not observed in NW children. Significant differences were found for: family history of OW/OB, birth weight (BW), age at menarche, presence of acanthosis nigricans, waist circumference (WC) >90th percentile. The WC was positively correlated with BP, TG, insulin, HOMA and Body mass index Z score and negatively with HDL in the study population.
We confirm obesity as a major determinant of CMRF and MS (40%), especially fat centralization. We stress the need to address obesity prevention plans in children and adolescents.
肥胖及其并发症在拉丁美洲国家正以流行的方式出现。
估计超重/肥胖（OW/OB）和正常体重（NW）青少年中心血管代谢危险因素（CMRFs）和代谢综合征（MS）的患病率，并检查相关变量。
在阿根廷七个省份对两组10至19岁的儿童进行了横断面比较研究。收集了关于饮食习惯、身体活动、人体测量和生化数据的调查，以确定CMRF和MS。使用了适用于儿童的世界卫生组织定义。
评估了1009名儿童；398名男性（39.4%），601名（59.6%）为NW，408名（40.4%）为OW/OB。OW/OB中被定义为CMRF的值的比例显著更高：3.7%的空腹血糖受损>110mg/dl；27.9%的胰岛素>15或20μU/l，因为他们处于青春期/青春期前；53.2%的稳态模型评估（HOMA）>2.5；45.6%的高密度脂蛋白（HDL）<40mg/dl；37.7%的甘油三酯（TG）>110mg/dl和13.5%的高血压（收缩压和/或舒张压百分位数>90）。OW/OB患者中MS的患病率为40.3%。NW儿童中未观察到MS。在以下方面发现了显著差异：OW/OB家族史、出生体重（BW）、初潮年龄、黑棘皮症的存在、腰围（WC）>第90百分位数。在研究人群中，WC与血压、TG、胰岛素、HOMA和体重指数Z评分呈正相关，与HDL呈负相关。
我们确认肥胖是CMRF和MS（40%）的主要决定因素，尤其是脂肪集中。我们强调需要制定针对儿童和青少年的肥胖预防计划。
