Institute of Chemical and Engineering Sciences, Jurong Island, Singapore, Singapore. dong
Colloids Surf B Biointerfaces. 2012 Jun 1;94:68-72. doi: 10.1016/j.colsurfb.2012.01.018. Epub 2012 Jan 25.
This work aimed at developing continuous and scalable nanoprecipitation synthesis of solid lipid nanoparticles (SLN) by mixing lipids acetonic solution with water using static mixers. The developed platform exhibited good control over the nanoprecipitation process and enabled the production of SLN below 200 nm at a throughput of 37.5-150 g/h (for 25 mg/ml lipid solution at a flow rate of 25-100 ml/min). Among the several process parameters investigated, the lipid concentration played primary role in influencing the size of the SLN and higher lipid concentration resulted in relatively larger particles. Fenofibrate, a model drug, has been successfully loaded into the SLN. Our work demonstrates the potential of applying static mixing-nanoprecipitation for continuous and large scale production of SLN.
本工作旨在通过使用静态混合器将脂质的丙酮溶液与水混合来开发连续且可扩展的固脂纳米粒 (SLN) 的纳米沉淀合成。所开发的平台对纳米沉淀过程具有良好的控制能力，并且能够以 37.5-150 g/h 的流速（对于 25 mg/ml 脂质溶液，流速为 25-100 ml/min）生产低于 200nm 的 SLN。在所研究的几个工艺参数中，脂质浓度对 SLN 的大小起着主要作用，较高的脂质浓度导致相对较大的颗粒。非诺贝特，一种模型药物，已成功载入 SLN。我们的工作证明了应用静态混合-纳米沉淀连续大规模生产 SLN 的潜力。
