State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, People's Republic of China.
Acta Biomater. 2012 May;8(5):1901-7. doi: 10.1016/j.actbio.2012.01.020. Epub 2012 Jan 24.
The aim of this study was to fabricate dual drug-loaded poly(lactic-co-glycolic acid) (PLGA)/mesoporous silica nanoparticles (MSNs) electrospun composite mat, with the two model drugs (fluorescein (FLU) and rhodamine B (RHB)) releasing in separate and distinct release kinetics. The PLGA-based electrospun mat loading with the same amount of FLU (5%, with respect to the weight of PLGA) and different amounts of RHB-loaded MSNs (5, 15 and 25%, with respect to the weight of PLGA) were prepared and studied for their releasing properties. The morphology of the composite mats was characterized by scanning electron microscopy and transmission electron microscopy. Finally, the release profiles of the dual drug-loaded electrospun mats were measured, and the results indicated that the FLU and RHB released from the PLGA/FLU/RHB-loaded MSNs electrospun mats showed separate and distinct profiles. Most of the FLU was released rapidly during the 324 h of the trial; however, RHB showed a sustained release behavior, and the release rate could be controlled by the content of the RHB-loaded MSNs in the electrospun mat.
本研究旨在制备载双药的聚乳酸-共-羟基乙酸（PLGA）/介孔硅纳米粒子（MSNs）电纺复合垫，两种模型药物（荧光素（FLU）和罗丹明 B（RHB））以单独且不同的释放动力学释放。用相同量的 FLU（相对于 PLGA 的重量的 5%）和不同量的负载 RHB 的 MSNs（相对于 PLGA 的重量的 5%、15%和 25%）装载的基于 PLGA 的电纺垫进行了制备和研究，以研究其释放性能。复合垫的形态通过扫描电子显微镜和透射电子显微镜进行了表征。最后，测量了载双药电纺垫的释放曲线，结果表明，从 PLGA/FLU/RHB 负载 MSNs 电纺垫中释放的 FLU 和 RHB 呈现出单独且不同的释放曲线。在试验的 324 小时内，大部分 FLU 迅速释放；然而，RHB 表现出持续释放行为，释放速率可以通过电纺垫中负载 RHB 的 MSNs 的含量来控制。
