Penick E C, Nickel E J, Powell B J, Bingham S F, Liskow B I
Department of Psychiatry, Kansas University Medical Center, Missouri.
J Stud Alcohol. 1990 Sep;51(5):443-7. doi: 10.15288/jsa.1990.51.443.
Both family history of alcoholism and the presence of additional psychiatric disorder in male alcoholic patients are associated with an earlier onset of problem drinking, greater alcoholism severity and poorer clinical outcomes. To assess the relative contribution of family history alone, a sample of 212 male alcoholics not positive for any other psychiatric disorder was selected and divided into those with a family history of alcoholism (FH+) or no family history of alcoholism (FH-) among first degree relatives. Although FH+ alcoholics reported a younger age of onset of problem drinking and greater severity of some alcohol-related sequelae, the differences were not as extensive or pronounced as those found in a previous study of a sample of psychiatrically heterogeneous patients (Penick et al., 1987). A bi-dimensional typology of alcoholism incorporating both additional psychiatric diagnoses and a positive family history of alcoholism is suggested.
酗酒家族史以及男性酗酒患者中存在其他精神障碍均与饮酒问题的更早出现、更严重的酗酒程度和更差的临床结果相关。为了单独评估家族史的相对影响，选取了212名未患有任何其他精神障碍的男性酗酒者样本，并根据一级亲属中有无酗酒家族史分为有酗酒家族史（FH+）或无酗酒家族史（FH-）两组。尽管FH+组酗酒者报告的饮酒问题起病年龄更小，且一些与酒精相关后遗症的严重程度更高，但这些差异不如先前对精神状态各异的患者样本研究（Penick等人，1987年）中发现的那么广泛或显著。有人提出了一种二维酗酒类型学，该类型学纳入了其他精神疾病诊断以及酗酒家族史阳性情况。
