Virji Mumtaz
Department of Cellular and Molecular Medicine School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK,
Top Curr Chem. 2009;288:139-56. doi: 10.1007/128_2008_15.
Microbial adhesion is generally a complex process, involving multiple adhesins on a single microbe and their respective target receptors on host cells. In some situations, various adhesins of a microbe may co-operate in an apparently hierarchical and sequential manner whereby the first adhesive event triggers the target cell to express receptors for additional microbial adhesins. In other instances, adhesins may act in concert leading to high avidity interactions, often a prelude to cellular invasion and tissue penetration. Mechanisms used to target the host include both lectin-like interactions and protein-protein interactions; the latter are often highly specific for the host or a tissue within the host. This reflective chapter aims to offer a point of view on microbial adhesion by presenting some experiences and thoughts especially related to respiratory pathogens and explore if there can be any future hope of controlling bacterial infections via preventing adhesion or invasion stages of microbial pathogenesis.
微生物黏附通常是一个复杂的过程，涉及单个微生物上的多种黏附素及其在宿主细胞上各自的靶受体。在某些情况下，微生物的各种黏附素可能以明显的层级和顺序方式协同作用，其中第一个黏附事件会触发靶细胞表达额外微生物黏附素的受体。在其他情况下，黏附素可能协同作用导致高亲和力相互作用，这通常是细胞侵袭和组织渗透的前奏。用于靶向宿主的机制包括凝集素样相互作用和蛋白质 - 蛋白质相互作用；后者通常对宿主或宿主体内的组织具有高度特异性。这一反思性章节旨在通过介绍一些特别是与呼吸道病原体相关的经验和想法，提供关于微生物黏附的观点，并探讨是否有可能通过预防微生物发病机制的黏附或侵袭阶段来控制细菌感染。
