Beader Natasa, Kalenić Smilja, Labar Boris
Zavod za mikrobiologiju, Klinicki zavod za klinicku i molekularnu mikrobiologiju Medicinskog fakulteta u Zagrebu, KBC Zagreb.
Lijec Vjesn. 2011 Nov-Dec;133(11-12):389-96.
In spite of improvements in diagnostics and prevention of CMV disease in recent decades, CMV infection still remains major concern in terms of diagnosis and therapy in recipients of allogeneic stem cells. Besides considerable morbidity with direct effects of CMV infection (hepatitis, gastrointestinal disease, pneumonia, retinitis), there are also indirect effects such as increased susceptibility to opportunistic infections and an increased risk of graft rejection and transplant-related mortality. Also, myelosuppression, nephrotoxicity and emergence of drug-resistant CMV strains may limit the use of antiviral agents for the control of CMV infection. The aim of this paper is to show the problems associated with CMV infection in recipients of allogeneic stem cells with special emphasis on diagnostic procedures and treatment or prophylaxis of CMV disease.
尽管近几十年来在巨细胞病毒（CMV）疾病的诊断和预防方面有所改进，但就异基因干细胞接受者的诊断和治疗而言，CMV感染仍然是一个主要问题。除了CMV感染的直接影响导致的相当高的发病率（肝炎、胃肠道疾病、肺炎、视网膜炎）外，还有间接影响，如对机会性感染的易感性增加以及移植排斥和移植相关死亡率的风险增加。此外，骨髓抑制、肾毒性和耐药CMV毒株的出现可能会限制抗病毒药物用于控制CMV感染。本文的目的是展示异基因干细胞接受者中与CMV感染相关的问题，特别强调CMV疾病的诊断程序以及治疗或预防。
