Ethun Kelly F, Cline J Mark, Appt Susan E
Wake Forest University Primate Center and the Department of Pathology-Comparative Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Comp Med. 2011 Oct;61(5):462-6.
For 21 mo after a bilateral ovariectomy, a 19-y-old ovariectomized cynomolgus macaque (Macaca fascicularis) continued to have menstrual cycles and measurable premenopausal estradiol and progesterone concentrations. Among these 10 menstrual cycles, 5 cycles were normal in duration and 5 were prolonged. At necropsy, a firm nodule was identified in the omental fat, and histologic evaluation confirmed the presence of ovarian tissue containing various stages of atretic follicles, a regressing corpora lutea, and a degenerating antral follicle. The endometrium and vaginal epithelium were atrophic. The occurrence of ectopic ovarian tissue in any form and location is a rare gynecologic condition in both women and nonhuman primates. Previously reported cases in nonhuman primates have been incidental findings at necropsy; therefore, the steroidogenic capacity and endocrine-related sequelae of such ovarian tissue in any nonhuman primate species is unknown. Based on structure, location, and relationship to normally situated ovaries, the ovarian tissue in this case was classified as a supernumerary ovary. To our knowledge, this is the first case report of a supernumerary ovary in a cynomolgus macaque. This report demonstrates that supernumerary ovaries in nonhuman primates can be biologically active for many years beyond sexual maturity and should be considered as a possible cause for vaginal bleeding and elevated ovarian hormone concentrations after ovariectomy.
在双侧卵巢切除术后21个月，一只19岁的去卵巢食蟹猴（猕猴）仍有月经周期，且可检测到绝经前雌二醇和孕酮浓度。在这10个月经周期中，5个周期持续时间正常，5个周期延长。尸检时，在网膜脂肪中发现一个坚实的结节，组织学评估证实存在卵巢组织，其中包含不同阶段的闭锁卵泡、退化的黄体和退化的窦状卵泡。子宫内膜和阴道上皮萎缩。任何形式和位置的异位卵巢组织的出现，在女性和非人灵长类动物中都是一种罕见的妇科疾病。此前在非人灵长类动物中报道的病例都是尸检时的偶然发现；因此，任何非人灵长类物种中这种卵巢组织的类固醇生成能力和内分泌相关后遗症尚不清楚。根据结构、位置以及与正常位置卵巢的关系，本病例中的卵巢组织被归类为额外卵巢。据我们所知，这是食蟹猴中额外卵巢的首例病例报告。本报告表明，非人灵长类动物中的额外卵巢在性成熟多年后仍可能具有生物学活性，应被视为卵巢切除术后阴道出血和卵巢激素浓度升高的可能原因。
