Amico J A, Zeleznik A J
Department of Medicine, University of Pittsburgh School of Medicine, Pennsylvania 15261.
Endocr Res. 1990;16(1):17-30. doi: 10.1080/07435809009035918.
The neurohypophysial hormone oxytocin has previously been found in the ovaries of several animal species. In ruminants ovarian oxytocin is postulated to have a luteolytic function, because of its high concentrations in the corpus luteum. In primates the role of ovarian oxytocin is not known. In the present study we measured the immunoreactive oxytocin and oxytocin-neurophysin content in paired ovaries removed from cynomolgus monkeys (Macaca fascicularis) during the late luteal phase of the cycle (Days 12-14 of the luteal phase or Days 26-28 of a menstrual cycle). Each animal was pulsed with synthetic gonadotropin-releasing hormone to maintain normal menstrual cyclicity. The concentration of oxytocin and its neurophysin during the late luteal phase was greater in the non-corpus luteum than corpus luteum-bearing ovary. By high pressure liquid chromatography and bioassay the oxytocin in both the corpus luteal and non-corpus luteal ovaries was similar to synthetic and posterior pituitary oxytocin. The finding of high concentrations of immunoreactive oxytocin in the non-corpus luteum-bearing ovary suggests that the function of ovarian oxytocin in primates may not be confined specifically to the corpus luteum.
此前已在多种动物的卵巢中发现神经垂体激素催产素。在反刍动物中，由于黄体中催产素浓度较高，推测其具有溶黄体功能。在灵长类动物中，卵巢催产素的作用尚不清楚。在本研究中，我们测量了在月经周期黄体晚期（黄体期第12 - 14天或月经周期第26 - 28天）从食蟹猴（猕猴）摘除的成对卵巢中免疫反应性催产素和催产素 - 神经垂体素的含量。每只动物都注射合成促性腺激素释放激素以维持正常月经周期。黄体晚期非黄体侧卵巢中催产素及其神经垂体素的浓度高于黄体侧卵巢。通过高压液相色谱法和生物测定法，黄体侧和非黄体侧卵巢中的催产素与合成催产素及垂体后叶催产素相似。在非黄体侧卵巢中发现高浓度的免疫反应性催产素表明，灵长类动物卵巢催产素的功能可能并不局限于黄体。
