在盐水中使用氟相磺酰胺有机催化剂实现高效不对称羟醛缩合反应。

Highly efficient asymmetric aldol reaction in brine using a fluorous sulfonamide organocatalyst.

机构信息

Gifu Pharmaceutical University 1-25-4, Daigaku-nishi, Gifu 501-1196, Japan.

出版信息

Org Biomol Chem. 2012 Mar 21;10(11):2209-13. doi: 10.1039/c2ob06955e. Epub 2012 Feb 14.

Abstract

A fluorous organocatalyst promotes direct asymmetric aldol reactions of aromatic aldehydes with ketones in brine to afford the corresponding anti-aldol products in high yield with up to 96% ee. Fluorous organocatalyst can be readily recovered by solid phase extraction using fluorous silica gel and reused without purification.

摘要

一种全氟有机催化剂促进了芳香醛与酮在盐水中的直接不对称羟醛反应，以高产率获得了相应的反式羟醛产物，对映选择性高达 96%。全氟有机催化剂可以使用全氟硅胶通过固相萃取轻易回收，并在无需纯化的情况下重复使用。