全氟烷磺酰胺有机催化剂在支链醛与乙烯砜不对称共轭加成反应中的应用。
Perfluoroalkanesulfonamide organocatalysts for asymmetric conjugate additions of branched aldehydes to vinyl sulfones.
机构信息
Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
出版信息
Molecules. 2013 Nov 25;18(12):14529-42. doi: 10.3390/molecules181214529.
Abstract
Asymmetric conjugate additions of branched aldehydes to vinyl sulfones promoted by sulfonamide organocatalyst 6 or 7 have been developed, allowing facile synthesis of the corresponding adducts with all-carbon quaternary stereocenters in excellent yields with up to 95% ee.
摘要
手性磺酰胺有机催化剂 6 或 7 促进支链醛与乙烯砜的不对称共轭加成已被开发出来，允许在高对映选择性（高达 95%ee）下以优异的收率轻松合成具有全碳季立体中心的相应加合物。
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