National Engineering Research Center for Biomaterials, Sichuan University, 610064, Chengdu, China.
Chem Commun (Camb). 2012 Mar 28;48(26):3170-2. doi: 10.1039/c2cc16744a. Epub 2012 Feb 13.
Based on photocrosslinkable PEGDMA and GelMA hydrogels, two "bottom-up" approaches ("circle-and-cross" and "layer-by-layer") were successfully developed to construct osteon-like structures with microchannel networks. Significantly, the "layer-by-layer" approach employing the GelMA hydrogel with a higher biocompatibility was more favorable for building biomimetic osteon.
基于光交联聚乙二醇二甲基丙烯酸酯（PEGDMA）和明胶甲基丙烯酸酯（GelMA）水凝胶，成功开发了两种“自下而上”的方法（“圈叉”和“层层”）来构建具有微通道网络的类骨结构。值得注意的是，采用生物相容性更高的 GelMA 水凝胶的“层层”方法更有利于构建仿生骨。
